Responsive nanoparticles deliver ARV-771 to tumor cells
A proof-of-concept nanoparticle system used hyaluronic acid for CD44-mediated tumor-cell targeting and glutathione-triggered disassembly to release ARV-771 and enable BRD4 ...
Tag: PROTAC
EP300 Degradation and AKT Inhibition Slow Osteosarcoma in Preclinical Models
A PROTAC that degrades EP300 combined with AKT inhibition slowed tumor growth and extended survival in patient-derived osteosarcoma mouse models, ...
How Breast Cancer Cells Outsmart Hormone Therapy—and the New Drugs Fighting Back
A new review details how ESR1 mutations, bypass signaling, and cell-cycle escape drive endocrine resistance in the most common breast ...
RNA acetylation enzyme NAT10 drives aortic valve calcification through PCSK9
A new iScience study shows that the RNA acetyltransferase NAT10 stabilizes PCSK9 mRNA through N4-acetylcytidine modification, driving the osteogenic transformation ...
Lost Tumour Suppressor on Chromosome 6q Drives Deadly Childhood Brain Cancer and Reveals a Drug Target
New research shows that loss of the tumour suppressor LATS1 on chromosome 6q drives Hippo pathway dysregulation in ultra-high-risk PFA ...
Proteomics and machine learning expose hidden toxicity in protein degrader drugs
High-throughput proteomics and machine learning revealed that cereblon-recruiting androgen receptor degraders inhibit mitochondrial complex I, and guided linker modifications that ...
Hidden Gatekeeper Protein Decides Which Vessel Signals Endothelial Cells Hear
Fluorescent live-cell reporters reveal that the protein FKBP12 acts as a gatekeeper deciding which TGF-β superfamily ligands activate SMAD signaling ...
From Molecular Glues to AI: The Technologies Reshaping Drug Discovery
A 58-article special issue of Molecular Diversity shows how synthetic chemistry, protein degraders, natural products, and AI-driven screening are converging ...
Plant Nanoparticles Deliver a Protein-Degrading Drug That Strikes Colorectal Cancer
Scientists have engineered a PROTAC molecule that destroys the RARα protein and delivered it via Polygonatum sibiricum exosome-like nanoparticles, markedly ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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