New Barcoded Yeast Library Maps Gene-Drug Interactions Across 262 Strains
A new CRISPR-Cas9 barcoded library, BarMix, profiles 262 diverse yeast strains against 33 compounds and reveals 281 chemogenomic interactions.
Tag: profiling
Clustering reveals two profiles of rewarding experiences after teen self-injury
A k-means clustering study of 132 clinical adolescents identified two subgroups based on subjective rewarding experiences immediately after nonsuicidal self-injury, ...
Blood Clotting Signals Stay Elevated in Women With Schizophrenia Despite Treatment Gains
A study of 50 women with paranoid schizophrenia found that elevated coagulation and fibrinolytic activity persisted after inpatient treatment even ...
Panchagavya compound improves salinity tolerance in rice seedlings
A laboratory study found that 1-methyl palmitate isolated from Panchagavya enhanced salinity-stress tolerance in rice seedlings through changes in autophagy, ...
Research report: MicroRNA profiling of filtering and non-filtering regions of human trabecular meshwork: changes with ageing and in glaucoma
Human donor tissue showed regional, age-related and glaucoma-associated microRNA patterns in the trabecular meshwork, identifying seven validated candidates while leaving ...
Rare Esophageal Cancer Subtype Reveals Diagnostic and Therapeutic Signatures Through Multi-Omics Profiling
Esophageal basaloid squamous cell carcinoma, one of the rarest and most aggressive forms of esophageal cancer, has long evaded detailed ...
Ebelin lactone from Bacopa shows strongest computational binding to neuritin and mortalin
A triterpenoid molecule derived from the memory herb Bacopa monnieri has been systematically profiled for the first time against a ...
Fibroblast Gene Profiling Reveals Inflammatory and Remodeling Signals in PIK3CA Overgrowth Spectrum
An exploratory single-patient study comparing affected and unaffected skin fibroblasts identifies candidate mRNA and microRNA alterations linked to inflammatory and ...
Early-onset colorectal cancer shows distinct immune-cell spatial patterns
A single-cell spatial analysis found similar overall immune-cell abundance but different local organization of regulatory and helper T-cell populations in ...
Tea resistance to anthracnose links enzymes, flavonoids and gene regulation
A controlled multi-omics study found faster enzyme responses, selective flavonoid changes and pathogen-interaction gene regulation in anthracnose-resistant tea cultivar ‘Shuixian ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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