CRISPR’s Journey From Molecular Scissors to Precision Genome Editors
A new review traces how CRISPR genome editing has evolved from blunt molecular scissors into increasingly precise therapeutic tools for ...
Tag: prime editing
Prime Assembly Enables Targeted Genomic Integration and Large-Scale DNA Rearrangements
A new prime editing-based strategy called prime assembly enables precise integration of large DNA fragments and programmable genomic rearrangements without ...
DNA-Binding Protein Fusions Supercharge PAM-Flexible, High-Precision Base Editing
Researchers have fused HMGN1 and VP64 to a PAM-flexible, truncated-CDA1 base editor, boosting precision and efficiency for editing nearly any ...
Prime Editing Gets a Size Upgrade: Researchers Insert Large DNA Fragments with Precision
Researchers report a prime-editing strategy that integrates large DNA fragments into precise genomic sites through donor-directed annealing without double-strand breaks.
Densely Modified RNA Guides Push Prime Editing to Nearly 70% Efficiency in Living Mice
Scientists have engineered densely chemically modified guide RNAs that boost prime editing efficiency in the mouse liver to nearly 70 ...
Donor-matched prime editing enables precise, library-ready kilobase DNA insertions
For years, the promise of precisely writing new DNA into the genome has been constrained by an awkward trade-off: the ...
flexiAsCas12a and Other Variants Expand Cas12a Nuclease Applications in Prime Editing
A new generation of CRISPR genome-editing enzymes could make it possible to rewrite DNA sequences that have remained out of ...
Prime Editing Uncovers Functional Synonymous Mutations
In a groundbreaking study that challenges long-standing biological dogma, researchers have unveiled the unexpected functional significance of synonymous mutations in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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