Your Zip Code May Shape Your Breast Cancer Tumor’s Genetics and Your Survival Odds
A large multi-institution study found that metastatic breast cancer patients in high deprivation neighborhoods had more TP53 mutations, lower use ...
Tag: precision oncology
Aptamer-Guided CRISPR-Cas9 Delivery Could Make Cancer Genome Editing Precise
A new review outlines how aptamer-guided nanocarriers could finally deliver CRISPR-Cas9 gene editing specifically to tumor cells, integrating molecular targeting, ...
Sarcoma Trials Offer Blueprint for Rarer Cancers Under New WHO and Global Trial Rules
A new review in eClinicalMedicine shows how sarcoma trials can guide the implementation of the 2024 WHO guidance and ICH ...
Pancreatic Cancer’s Moving Target: New Framework Calls for Continuously Evolving Treatment
A new review proposes a Dynamic Precision Oncology framework that monitors pancreatic cancer's evolving resistance mechanisms through longitudinal genomic, liquid ...
Lab-Grown Tumours and Digital Twins Bring Precision Therapy to Oesophageal Cancer
A new review maps the laboratory models—from organoids to humanised mice to computational pipelines—that could finally bring personalised treatment to ...
ROS1 Fusion Subtype Shapes Survival in Advanced Lung Cancer, Real-World Data Show
A real-world study of 55 patients with advanced ROS1-rearranged non-small cell lung cancer shows that fusion subtype, PD-L1 expression and ...
Dark DNA’s Long RNAs Emerge as Master Regulators of Colorectal Cancer
A major new review shows that long non-coding RNAs orchestrate the colorectal cancer tumour microenvironment, offering new biomarkers and therapeutic ...
Machine Learning Map Reveals Hidden Paralog Vulnerabilities Across 1,005 Cancer Cell Lines
Researchers have built a machine learning framework that predicts context-specific synthetic lethal vulnerabilities between paralog gene pairs across 1,005 cancer ...
Beyond KRAS G12C: New Drug Wave Targets Once-Undruggable Cancer Driver
A new review maps the fast-moving landscape of next-generation KRAS inhibitors, degraders, and combination strategies now advancing beyond the first ...
Neutrophil Traps That Feed Tumors: DNA Webs Emerge as Drivers and Markers of Cancer Progression
A new review details how neutrophil extracellular traps drive tumor growth, metastasis and treatment resistance while emerging as both biomarkers ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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