Mitochondrial Dysfunction Emerges as a Shared Network Behind Osteoarthritis Pain
A review proposes that mitochondrial dysfunction across cartilage, synovium, subchondral bone and neural compartments forms a shared pathological network linking ...
Tag: Precision medicine
Blocking ERG Protein Radiosensitizes ERG-Positive Prostate Cancers by Disabling DNA Repair
New research shows that inhibiting the ERG protein, overproduced in about half of prostate cancers, selectively impairs DNA double-strand break ...
AI Subtyping Suggests Polycystic Ovarian Syndrome Is Four Distinct Conditions
A review argues that polycystic metabolic ovarian syndrome is best understood as four biologically distinct subtypes identified through multi-omics data ...
Review proposes network-level GPCR control against multiple aging processes
A peer-reviewed literature review proposes that rebalancing G protein-coupled receptor signaling across multiple pathways could influence several aging-related processes, but ...
Molecular obesity therapies advance, but precision prescribing remains largely unproven
A 2026 review finds that multi-agonist obesity drugs can produce substantial weight loss, but biomarker and pharmacogenomic tools are not ...
BabyMERIT Trial to Test Trametinib for Severe Infantile Hypertrophic Cardiomyopathy
The NIH-funded BabyMERIT trial will test trametinib in 25 infants with severe hypertrophic cardiomyopathy associated with Noonan syndrome and related ...
Beyond generalist AI: purpose-built foundation models for transplantation
A 2026 Perspective proposes a five-part design and deployment roadmap for foundation models that jointly represent donor, recipient and graft ...
Brazilian cancer biobank targets precision prevention for diverse population
A Hospital de Amor biobank has collected nearly 40,000 blood samples from more than 4,000 Brazilians to develop cancer risk ...
Multi-omics in coronary atherosclerosis: mechanistic insights and advances in precision diagnosis and treatment
A narrative review finds that multi-omics can illuminate coronary plaque biology, but most biomarkers and prediction models remain investigational.
Gut microbiome may influence variable responses to MASH therapies
A review finds that microbial metabolites may influence variable responses to MASH therapies, but direct clinical evidence linking gut microbial ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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