Scientists Map the Earliest Steps of Polycomb Gene Silencing in Human Embryos
A Nature Genetics study shows that the histone mark H2Aub laid down by PRC1 guides the reestablishment of Polycomb repression, ...
Tag: PRC2
Childhood Brain Tumor Study Exposes KDM2B as a Treatable Weak Spot in High-Risk Medulloblastoma
A comprehensive epigenetic analysis led by St. Jude and KiTZ identified the chromatin regulator KDM2B as an essential, selective dependency ...
Epigenetic Drug Valemetostat Shows Dual Action Against HTLV-1 Eye Inflammation
A new study shows that the dual EZH1/2 inhibitor valemetostat counteracts HTLV-1-induced epigenetic changes in retinal cells and suppresses viral ...
Fungal enzyme RTT109 proves essential for inheriting silenced chromatin
A new study in Neurospora crassa shows that the replication-linked histone acetyltransferase RTT109, acting independently of its known product H3K56 ...
Why Some Neurons Survive: Identity Maintenance May Set the Threshold of Neurodegeneration
A new PLOS Biology essay proposes that a neuron's capacity to maintain its subtype-defining gene-regulatory machinery may set the stress ...
Childhood Brain Tumor Study Uncovers KDM2B as a Selective Epigenetic Vulnerability
A comprehensive epigenomic map of medulloblastoma reveals that the chromatin regulator KDM2B sustains the highest-risk tumor subgroups by locking neuronal ...
First Mosaic Case Rewrites the Genetic Story of a Rare Overgrowth Syndrome
Researchers report the first known case of Cohen–Gibson syndrome caused by a mosaic EED variant, expanding the mutational spectrum of ...
Aging and Rejuvenation Converge on the Same Epigenetic Switch in Mouse Skin
Whole-genome sequencing of mouse skin shows that aging and partial reprogramming converge on PRC2 target genes, where methylation entropy rises ...
Zebrafish Reveal How Polycomb Complexes Sculpt the Heart and Fins
A new review shows that Polycomb repressive complexes PRC1 and PRC2 are essential for zebrafish heart looping, contraction and pectoral ...
Lost Epigenetic Guardian CBX7 Emerges as Key Driver and Drug Target in Glioblastoma
A new review shows that the epigenetic regulator CBX7 acts as a tumor suppressor in glioblastoma, and that restoring its ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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