Deep Learning Reads Molecular Dynamics to Decode Protein Allostery
A new graph neural network framework called AlloPool distills molecular dynamics simulations into minimal, time-resolved interaction networks that reveal how ...
Tag: PLOS Biology
How Nerve Cells Measure Their Wires: Piezo1 Sets Myelin Length to Match Axon Size
A new PLOS Biology study shows that the mechanosensitive ion channel Piezo1 allows oligodendrocytes to sense axon diameter and locally ...
How a Pathogen Hijacks Nerve Signals to Break Down a Worm’s Skin
Researchers discovered that the bacterium Pseudomonas aeruginosa exploits neuronal signaling in C. elegans to impair lysosomal function and disrupt collagen ...
Enzyme Tag-Team Lets Caterpillarpests Beat Plant Toxins and Expand Their Menu
A coordinated P450 and UGT33 detoxification cascade allows the generalist moth Helicoverpa armigera to tolerate furanocoumarin plant toxins, while its ...
Antibodies Against Phage Fiber and Nozzle Proteins Undermine Acinetobacter Phage Therapy
New research shows that antibodies targeting the fiber and nozzle proteins of an Acinetobacter baumannii phage block infection and accelerate ...
Ancient Chromosomal Inversions Shape Sexual Traits in Wild Guppies
A study of Trinidadian guppies finds that ancient chromosomal inversions, some millions of years old, are maintained by female preference ...
Why One Antibody Rules Them All: Epistasis Blocks Broad Flu Protection
Deep mutational scanning of the CR9114 antibody reveals that epistasis and pleiotropy make cross-reactive breadth against both influenza A and ...
Fruit Fly Glial Atlas Reveals How the Brain’s Support Cells Diversify
A single-cell atlas of the developing Drosophila visual system traces how glial cells diversify from larvae to adulthood and reveals ...
Every Liver Cell Counted: Whole-Organ Microscopy Reveals How Organs Grow
A new whole-organ expansion microscopy technique has counted every hepatocyte in the adult zebrafish liver, revealing a 538-fold growth burst ...
Brain Timelines Unfold From Sensorimotor to Association Cortex Before Settling in Adulthood
A large multi-cohort neuroimaging study shows that the brain's intrinsic timescales mature hierarchically along the sensorimotor-to-association cortical axis during youth ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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