Rutin Disrupts hnRNP L Condensates to Rewire Fibrotic Metabolism in Pulmonary Fibrosis
A new study in Frontiers in Pharmacology suggests that the natural flavonoid rutin binds the splicing factor hnRNP L, interferes ...
Tag: PKM2
Inflammatory Fatty Acid Drains Kidney Cells’ Energy Supply, Worsening Podocyte Damage
New research shows that arachidonic acid released during infection worsens podocyte kidney injury by disrupting PKM2-linked glycolytic metabolism and mitochondrial ...
Scientists Uncover a Sugar-Burning Switch That Drives Liver Scarring
A new Nature Communications study shows that the ubiquitin ligase PRPF19 drives hepatic stellate cell activation and liver fibrosis by ...
Viral protein hijacks a metabolic enzyme to drive Kaposi’s sarcoma spread
Researchers have shown that the KSHV protein vIRF3 binds and activates the metabolic enzyme PKM2, raising acetyl-CoA levels that drive ...
Motor Protein KIFC1 Fuels Cervical Cancer Radioresistance Through a Splicing-Driven Glycolytic Switch
New research reveals that the motor protein KIFC1 drives cervical cancer radioresistance by shuttling the splicing factor SRSF3 into the ...
Tiny Micropeptide Blocks Vascular Calcification by Tagging PKM2 for Destruction
A newly identified micropeptide called PKM2 AP inhibits vascular calcification by acting as a molecular glue that triggers ubiquitin-mediated degradation ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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