Multi-Omics Map of Chinese Cervical Cancer Patients Reveals New Drug Targets
An integrated multi-omics study of 112 Chinese cervical cancer patients reveals key driver mutations, immune phenotypes, and promising therapeutic targets.
Tag: PIK3CA
β-Catenin Inhibitors Show Potent Activity Against Double-Mutant Endometrial Cancer in Preclinical Study
A new preclinical study shows that the β-catenin/CBP inhibitor ICG-001 selectively kills endometrial cancer cells carrying both PIK3CA and CTNNB1 ...
Post-mortem MRI reveals how fetal brains first begin to form the folds of polymicrogyria
By pairing high-resolution post-mortem MRI with neuropathology in four fetuses at 21 weeks, researchers have captured the earliest stages of ...
Mutational Map of Gallbladder Cancer Reveals New Paths to Precision Therapy
A new review maps the recurrent mutations and signaling crosstalk driving gallbladder cancer, identifying ERBB2 and KRAS as hub targets ...
Rare Metaplastic Breast Cancer Shows Weaker Response to Antibody-Drug Conjugate
A large single-center analysis finds that metastatic metaplastic triple-negative breast cancer responds less well to sacituzumab govitecan than typical triple-negative ...
Beyond PIK3CA: Genetic Study Redraws the Map of Childhood Vascular Malformations with Overgrowth
A multicenter Italian study of 41 children shows that non-PIK3CA vascular malformations with overgrowth are genetically and clinically so overlapping ...
Tea Compounds Show Surprising Power Against Cancer and Aging Proteins
A new network pharmacology study identifies 14 tea phytochemicals that strongly bind the cancer- and metabolism-linked hub proteins PIK3CA, AKT1, ...
Gene Amplifications, Not Mutation Load, Mark Poor Survival in Aggressive Bladder Cancer
A Swiss genomic study of muscle-invasive bladder cancer finds that oncogene amplifications, rather than tumor mutational burden or microsatellite instability, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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