Why Beta-Lactams and Macrolides May Work Better Together Than Alone
A comprehensive review finds that beta-lactam–macrolide combination therapy shows its clearest benefit in severe community-acquired pneumonia, while most proposed synergy ...
Tag: Pharmacokinetics
Subcutaneous Immunoglobulin Gains Ground Over IV Infusions for Cancer-Related Immune Deficiency
A new review finds that subcutaneous immunoglobulin replacement offers steadier antibody levels, fewer systemic side effects and home-based convenience compared ...
Organ-on-Chip Meets Digital Twin: Systematic Review Maps the Future of Drug Development
A new systematic review of 123 studies shows that pairing organ-on-chip devices with digital twin computational models is rapidly maturing ...
Children Are Being Left Behind as Antifungal Resistance Gathers Pace, Global Pediatric Group Warns
A new International Pediatric Association analysis reveals that none of five novel antifungal drugs in late-stage development has pediatric efficacy ...
Continuous or Extended? Landmark Analysis Reshapes How ICUs Deliver Lifesaving Beta-Lactam Antibiotics
A Bayesian network meta-analysis of 25 randomized trials suggests extended beta-lactam infusion matches continuous infusion in critically ill patients while ...
Springer Nature Honors Pharmaceutical Journal Editors with 2026 Distinction Awards
Springer Nature has named ten editors of the Journal of Pharmaceutical Investigation as recipients of its 2026 Editor of Distinction ...
Why Big PEGs Never Cross the Gut Wall: New Review Maps the Science and Safety of Osmotic Laxatives
A University of Milan review confirms that high molecular weight PEG laxatives are negligibly absorbed by the gut, tracing the ...
New Computational Model Explains Why Glucosamine Trials Keep Disagreeing
A new quantitative systems pharmacology model links glucosamine's joint-level exposure to cartilage biology and clinical outcomes, offering a mechanistic explanation ...
Isoflurane lingers in the body long after anesthesia ends, piglet study reveals
A new piglet study provides the first integrated characterization of isoflurane uptake and disposition kinetics, revealing that only 14.5 percent ...
Drug Penetration Into Lung Cavities Predicts Which Tuberculosis Regimens Can Be Shortened
A validated translational platform linking lesion drug penetration to Phase 3 trial outcomes offers a new way to design shorter ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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