Severe obesity complicates ICU drug dosing, review concludes
A narrative review concludes that severe obesity can complicate ICU drug dosing and supports individualized regimens based on pharmacokinetic variability ...
Tag: pharmacodynamics
Mapping the subcellular pharmacokinetic-pharmacodynamic landscape: a systems-pharmacology framework for predicting combination therapies against intracellular bacterial infections
A targeted narrative review proposes a systems-pharmacology framework for designing antibiotic combinations around drug exposure, bacterial state and location within ...
Single-center blood-culture analysis maps antibiotic resistance and dosing challenges in sepsis
A retrospective single-center analysis of 760 blood cultures from patients with sepsis found positive growth in 25.8% of samples and ...
Why a Single EC50 Cannot Capture the True Power of an Antiviral Drug
A new review argues that conventional EC50 and EC90 values are context-dependent dynamic phenotypes shaped by viral kinetics, host-cell biology, ...
Drug Penetration Into Lung Cavities Predicts Which Tuberculosis Regimens Can Be Shortened
A validated translational platform linking lesion drug penetration to Phase 3 trial outcomes offers a new way to design shorter ...
Transient Dynamics Reveal Hidden Weaknesses in Standard Antibiotic Testing
A new computational study of Pseudomonas aeruginosa shows that transient population dynamics and inoculum size fundamentally reshape antibiotic susceptibility, prompting ...
First-in-Human Trial Shows PEGylated Uricase HZBio1 Is Well Tolerated and Slashes Uric Acid
A first-in-human phase 1a trial in China found that single intramuscular doses of the PEGylated recombinant uricase HZBio1 were well ...
Herbal Remedies Quietly Reshape Blood Thinner Levels in Healthy Volunteers
A clinical trial finds that the traditional Korean formulations Bojungikgitang and Cheongsanggyeontongtang substantially raise or lower edoxaban exposure in healthy ...
Receptor Occupancy Fails to Predict Immune Activation in Pembrolizumab Dosing Study
A translational modelling study finds that PD-1 receptor occupancy does not predict immune activation during pembrolizumab therapy, challenging current dosing ...
PET Imaging Reveals Whether Immunotherapy Drugs Actually Reach Their Tumour Targets
Researchers are using PD-L1-targeted PET/CT imaging to directly visualise whether the immunotherapy drug atezolizumab saturates its target in tumours, offering ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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