Gut Metabolite Genes Could Predict Colorectal Cancer Survival and Immunotherapy Response
Researchers built a four-gene signature based on propionate metabolism that stratifies colorectal cancer patients by survival risk and links tumor ...
Tag: PD-L1
Tiny Vesicles, Big Problem: How Exosomes Drive Cancer Immunotherapy Resistance
A new review in Molecular Cancer explains how tumor-derived exosomes act as mobile signaling hubs that spread immune suppression, drive ...
New 3D Fluorescence Imaging Technique Maps PD-L1 in Lung Cancer to Gauge Immunotherapy Response
An exploratory study in BMC Medicine presents a three-dimensional NIR-II fluorescence molecular tomography system fused with X-ray CT that quantifies ...
Indirect Trial Comparison Suggests Retifanlimab Edges Out Avelumab in Metastatic Merkel Cell Carcinoma
A matching-adjusted indirect comparison of two landmark trials suggests retifanlimab significantly prolongs progression-free survival compared with avelumab in metastatic Merkel ...
Tumor Protein CEMIP Hijacks Immune Cells to Fuel Colorectal Cancer Drug Resistance
New research reveals that the tumor protein CEMIP drives extracellular vesicle output, reprograms macrophages by disrupting HSP90-JAK2 signaling, and enables ...
Cancer Cells Rewire Immune Neutrophils Through a Fumarate-Driven Metabolic Switch, Study Finds
A new Nature Cancer study reveals that the kinase GSK3β in colorectal tumor cells drives fumarate accumulation that epigenetically reprograms ...
How Your Face Ages: Genes, Inflammation and Blood Fats Reveal the Biology of Looking Older
A UK Biobank study of 435,078 people uses causal inference and multi-omics to map sex-specific inflammatory and lipid pathways that ...
PET Scan Glucose Uptake Offers Clues to Immunotherapy Biomarker in Esophageal Cancer
A retrospective study of 89 patients finds that 18F-FDG PET/CT metabolic parameters, particularly SUVmax, are statistically associated with PD-L1 expression ...
Immunotherapy Brings Three-Year Survival in Rare, Usually Fatal Lung Vascular Cancer Syndrome
A Japanese case report describes more than three years of progression-free survival in pulmonary tumour thrombotic microangiopathy after prompt nivolumab ...
Immune Cells Cluster Around Blood Vessels to Predict Lung Cancer Immunotherapy Success
New spatial profiling research shows that the positioning of cytotoxic T cells around tumor blood vessels predicts which non-small cell ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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