Cancer Immunotherapy Triggered a Heart Attack in One Patient—Here’s What It Reveals
A new case report describes a 70-year-old lung cancer patient with no cardiovascular risk factors who suffered a massive heart ...
Tag: PD-L1
Blood Cell Clues Reveal Who Benefits When Radiotherapy Meets Immunotherapy in Lung Cancer
A phase II trial of radiotherapy followed by atezolizumab in relapsed small cell lung cancer found that radiation-induced changes in ...
DNA Repair Gene Mutations Predict Dramatically Better Immunotherapy Outcomes in Colorectal Cancer
A study of 450 colorectal cancer patients shows that POLE and POLD1 proofreading gene mutations predict markedly better immunotherapy response ...
Immune Cell Resident Gene RBPJ Emerges as Key to Lung Cancer Immunotherapy Success
A new single-cell study identifies the transcription factor RBPJ and CD103-positive tissue-resident memory T cells as central drivers of successful ...
Nanoparticle Paclitaxel Boosts Immunotherapy Response in Advanced Lung Cancer Trial
A phase II trial found that nanoparticle polymeric micellar paclitaxel combined with carboplatin and sintilimab produced an objective response rate ...
BK Virus Kidney Infection Shows Broad Immune Disruption in Transplant Patients
A combined transcriptomic and histological study of kidney biopsy tissue reveals widespread immune activation, checkpoint upregulation, and altered T-cell dynamics ...
Triple Therapy Shows Edge in Lung Cancer Lacking Targetable Mutations
A new network meta-analysis of five trials involving 2,452 patients finds that triple therapy combining immunotherapy, antiangiogenic antibodies, and chemotherapy ...
Immune-Boosted Chemo Cuts Death Risk by a Third in Advanced Esophageal Cancer, Landmark Analysis Finds
A revised meta-analysis of six phase III trials shows first-line PD-1 inhibitor plus chemotherapy reduces the risk of death by ...
How Sleep Apnea and Obesity May Quietly Fuel Cancer Growth
A new perspective in the International Journal of Obesity argues that obesity, obstructive sleep apnea, and cancer form an interconnected ...
Antibody-Drug Conjugate RC48 Ignites Ferroptosis to Rally Immune Cells Against HER2 Breast Cancer
New research shows the anti-HER2 antibody-drug conjugate disitamab vedotin kills breast cancer cells through ferroptosis, releasing danger signals that activate ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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