Hidden p53 Variant Δ246p53 Emerges as a DNA Damage Sentinel Driving Cellular Senescence
Researchers have discovered Δ246p53, a conserved 18-kilodalton p53 isoform translated from codon 246 that responds to DNA damage and enhances ...
Tag: p21
Radiation Turns Childhood Brain Tumor Cells Senescent—and Senolytic Drugs Can Kill Them
New research shows that gamma irradiation drives p53 wild-type medulloblastoma cells into a senescent state that senolytic drugs such as ...
Experimental Drug SMIP004 Hunts Down Dormant Cancer Cells Left Behind by Chemotherapy
Researchers report that the mitochondria-targeting compound SMIP004 selectively kills therapy-induced senescent cancer cells by promoting degradation of the AMPK-stabilized metabolic ...
Senolytic Drugs and Aerobic Exercise Each Rejuvenate the Aging Mouse Heart
A nine-month study in mice shows that chronic senolytic treatment and aerobic exercise each reduce senescent cell markers in the ...
Mini-GRID Radiotherapy Curbs Cellular Senescence While Keeping Its Anti-Tumor Punch in Glioma Cells
A preclinical study finds that spatially fractionated mini-GRID radiotherapy preserves the growth-inhibitory effect of radiation in glioma cells while markedly ...
Cellular Program Behind Aging May Also Shape Embryos, CHARGE Syndrome Review Suggests
A new review proposes that misregulation of developmental senescence, a transient embryonic cell-arrest program, may contribute to the congenital defects ...
Plant-Derived Molecule KGA-1002 Strikes GRP94 to Collapse Liver Cancer’s Protein Folding Machinery
A synthetic guaianolide dimer derived from a plant sesquiterpenoid selectively covalently binds the ER chaperone GRP94 at serine 106, triggering ...
Bortezomib Triggers ROS-Driven Mitochondrial Cell Death and Blocks SKP2 Signaling in Skin T-Cell Lymphoma
New research shows the proteasome inhibitor bortezomib kills cutaneous T-cell lymphoma cells through ROS-dependent mitochondrial apoptosis while suppressing the SKP2-p21/p27 ...
Aging Stem Cells Lose Their Healing Power, Landmark Review Finds
A systematic review of 45 studies finds that senescent mesenchymal stem cells consistently lose proliferative and migratory capacity and may ...
Aging Cells Ratchet Up a Gene Called EYA4, and Silencing It Delays Senescence
New research shows that the age-upregulated gene EYA4 drives cellular senescence by partnering with the transcription factor SIX2 to boost ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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