Hidden RNA switches that control the cellular recycling behind bone loss
A new review maps how microRNAs, long non-coding RNAs and circular RNAs tune autophagy in bone cells, opening a fresh ...
Tag: osteoclasts
How Exercise Reprograms Glucose Metabolism to Fight Osteoporosis
A new review reveals that exercise protects against osteoporosis by reprogramming how bone cells burn glucose, linking glycolysis, lactate signaling, ...
Sugar Metabolism Emerges as a Master Switch Controlling Bone Rebuilding
A new review argues that glycolysis acts as a signaling hub in bone remodeling, with glycolytic enzymes and metabolites such ...
Cell Death Debris Turns Out to Be a Master Regulator of Bone Renewal
A new review in the Journal of Translational Medicine details how vesicles released by dying cells actively regulate bone remodeling ...
Single Transcription Factor PU.1 Rapidly Converts Fibroblasts into Macrophage-Lineage Cells
Researchers at Mie University show that the transcription factor PU.1 alone can rapidly reprogram fibroblasts into transplantable macrophage-lineage cells, bypassing ...
Smart Bone-Seeking Nanocarrier Releases Osteoporosis Drug Only Where Oxygen Runs Low
A hypoxia-responsive, bone-targeted calixarene nanocarrier delivers raloxifene to osteoporotic bone, restores redox balance, and rebuilds trabecular microarchitecture in ovariectomized mice.
Zebrafish Take the Spotlight as a Powerful New Model for Studying Osteoporosis
A systematic review of 105 studies shows that chemically induced zebrafish models reliably reproduce key hallmarks of osteoporosis, but the ...
Bone-Eating Cells Sabotage the Brain’s Drainage System to Help Tumors Invade the Dura
A new Nature study shows that tumor-recruited osteoclasts secrete angiopoietin-2 to destroy meningeal lymphatic vessels in dural metastasis, and that ...
SIRT1 Emerges as a Plausible Molecular Link Between Bone Marrow Edema and Bone Remodeling
A new review synthesizes evidence that the NAD+-dependent deacetylase SIRT1, a master regulator of bone remodeling, may also influence bone ...
Scientists Set the Bar for What Counts as a Real Bone Organoid
A new review in Materials Today Bio proposes the first operational definition of a bone organoid and finds that most ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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