Metabolic Protein Tags Emerge as Key Players in Disc Degeneration
A new review maps how metabolite-driven protein modifications such as lactylation, O-GlcNAcylation and succinylation may link the disc's harsh metabolic ...
Tag: nucleus pulposus cells
Disc Degeneration Traced to a Histone Switch That Silences the Cell’s Mitochondrial Cleanup Crew
A new study shows that the chromatin protein CBX3 accelerates disc degeneration by silencing the SESN2 gene through H3K9me3 marks, ...
Rare Sugar D-Allose Rewires a Mitochondrial Stress Circuit to Slow Disc Degeneration
A new study shows that the rare sugar D-allose restores mitophagy, suppresses cGAS–STING signalling and preserves the cytoprotective peptide ADM2 ...
Rapamycin Nanoparticles Rejuvenate Aging Spine Discs by Silencing a Cellular Aging Switch
Rapamycin-loaded nanoliposomes inhibited mTORC1-driven senescence in rat disc cells and slowed intervertebral disc degeneration in vivo, pointing toward an injectable ...
Ancient Chinese Herbal Formula Shows Promise Against Disc Degeneration
A classical Chinese herbal formula, Juanbi Tang, attenuates intervertebral disc degeneration in rats by suppressing p38MAPK/NF-κB signaling, activating Atg5-dependent autophagy, ...
Epigenetic Enzyme Keeps Spinal Disc Cells Metabolically Balanced, Study Finds
New research shows that the epigenetic enzyme HDAC1 preserves metabolic balance in nucleus pulposus cells through post-translational modification interactions with ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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