CUL3 mutations reshape NRF2 control in TP53-mutant lung cancer
A multi-cohort genomic and molecular dynamics study links CUL3 mutations to TP53-associated NRF2 dysregulation in EGFR-driven non-small cell lung cancer ...
Tag: non-small cell lung cancer
RAS Inhibitor Daraxonrasib Redefines Pancreatic Cancer Treatment After FDA Approval
A phase 3 trial of the pan-RAS inhibitor daraxonrasib doubled median overall survival in previously treated metastatic pancreatic cancer, prompting ...
Nomogram Predicts Survival in Advanced EGFR-Mutant Lung Cancer on TKIs
A retrospective study of 250 patients developed a nomogram using age, EGFR genotype, CYFRA21-1 level, and TKI generation to predict ...
New Protocol Aims to Predict Serious Treatment Side Effects in Advanced Lung Cancer
A newly published protocol details how UK researchers plan to build and internally validate a counterfactual risk score predicting serious ...
Tumor TNF-α Drives CCL4-Producing Neutrophils Linked to Immunotherapy Resistance in Lung Cancer
A new study links tumor-derived TNF-α, CCL4-high tumor-associated neutrophils, and suppressed T-cell activity to immunotherapy resistance in non-small cell lung ...
Japanese Real-World Data Reproduce Trial Survival Signals in Lung Cancer
A Japanese historical cohort study reconstructed progression-free survival of 3.5 months in 75 atezolizumab-treated lung cancer patients from unstructured electronic ...
Plant lignan compounds show direct binding to EGFR in computational and lab study
An integrated computational and biophysical study found that cleistanthin A and diphyllin derivatives bind the EGFR tyrosine kinase domain, with ...
MD Anderson Studies Point to Blood Tests, Vaccines and Pre-Surgery Immunotherapy at ESMO 2026
New findings presented at the ESMO Congress 2026 cover ctDNA monitoring in lung and breast cancer, a re-vaccination strategy for ...
Fungal-Derived Compound DM28 Boosts Immunoradiotherapy in Lung Cancer Model
A preclinical mouse study reports that the fungal-derived compound DM28 induces SLC3A2-linked ferroptosis and increases activated T cell infiltration when ...
New Tool Distills Tumor Family Trees Into a Few Reliable Branches
Researchers have introduced Sapling, a computational method that summarizes the many equally plausible tumor phylogenies inferred from bulk DNA sequencing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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