Time to Study the RNA Itself: Rebalancing the Non-Coding RNA Research Agenda
A new Editorial in Experimental & Molecular Medicine argues that lncRNA and circRNA research must shift from saturated downstream target ...
Tag: non-coding RNA
Hidden RNA Brake Inside Mitochondria Slows Fat Cell Formation in Obese Mice
Scientists have identified a mitochondria-localized circular RNA, named BRAKE, that disrupts ATP synthase assembly to restrain fat cell formation and ...
Circular RNA circLPAR3 blocks ferroptosis to fuel chemotherapy resistance in prostate cancer
Researchers at Nanjing Medical University report that the m6A-stabilized circular RNA circLPAR3 suppresses ferroptosis through the PCBP2/CHAC1 axis, driving docetaxel ...
Circular RNA Revealed as Hidden Brake on Colorectal Cancer Growth
Researchers report that the circular RNA circMTCL1, sharply depleted in colorectal cancer tumors, suppresses cancer cell growth by sponging miR-145-5p, ...
Cigarette Smoke Sends a Cancer Signal: Exosomal circ55033 Drives Bladder Tumor Aggression
Researchers report that cigarette smoke drives bladder cancer aggressiveness through exosome-delivered circ55033, which sponges miR-1286 to promote EMT and cancer ...
CRISPR-Cas13 Screens Reveal Hundreds of Long Non-Coding RNAs Cells Cannot Live Without
A transcriptome-scale CRISPR-Cas13 screening platform called CaRPool-seq has identified 778 essential long non-coding RNAs in human cells, including 46 required ...
New Genomics Hub Spotets Hidden RNA Signals That Automated Pipelines Keep Missing
A new open-access bioinformatics platform called lncRNA Seeker Hub aggregates RNA sequencing evidence across whole cohorts and supports manual transcript ...
Tiny Blood RNAs Emerge as Early Warning Signals of Sepsis in Newborns
A validation study of 64 septic newborns finds that circulating microRNAs miR-15a, miR-132, and miR-223 are significantly dysregulated and may ...
Tiny RNA Fragment Emerges as Hidden Driver of Osteoarthritis Progression
Researchers report that the snoRNA-derived fragment sdRNA-D21 drives chondrocyte apoptosis in osteoarthritis by impairing BAG2-mediated ER-phagy and silencing DEPTOR, identifying ...
Tiny RNA Fragment in Sperm Tracks Severity of Varicocele-Linked Infertility
Researchers report the first evidence that sperm tRNA-derived fragments are altered in varicocele, with tRF-36 significantly downregulated in the most ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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