Review maps cell-specific MAVS and inflammasome signaling in HIV-1
A review finds that HIV-1 suppresses MAVS-dependent antiviral signaling in myeloid cells while distinct IFI16 and CARD8 pathways can promote ...
Tag: NLRP3
Blood RNA markers illuminate protein-modification networks in heart attacks
A transcriptomic study identified GABARAPL1, PELI1 and NLRP3 as elevated blood RNA markers associated with acute myocardial infarction, while highlighting ...
Eight-Gene Blood Test Shows Striking Accuracy in Detecting Heart Attacks
Researchers used nested machine learning on public blood transcriptome data to derive an eight-gene index that diagnoses acute myocardial infarction ...
Leftover Roots of a Korean Medicinal Herb Quiet a Brain Inflammation Trigger
Residue extracts of Angelica gigas retained decursin and decursinol angelate, which bound NLRP3 and dampened microglial inflammasome activation in cells ...
Febuxostat, a gout drug, shows promise as topical treatment for psoriasis in mice
A new study reports that topical febuxostat ointment reduced psoriasis-like skin inflammation in mice, improved antioxidant defenses, and altered expression ...
Inflammasome Biomarkers Could Predict Which Wounds Heal and Which Turn Chronic
A new review argues that inflammasome-derived molecular biomarkers could predict wound outcomes, distinguish healing from chronic inflammation, and guide precision ...
Overactive Inflammasome in Artery Muscle Cells Drives Dangerous Vessel Thickening in Mice
A new mouse study shows that hyperactive NLRP3 inflammasome signaling within vascular smooth muscle cells drives inflammation, pyroptosis, lipid accumulation, ...
Bioprinted Coronary Artery Model Recreates Kawasaki Disease in the Lab
A 3D bioprinted human coronary artery equivalent reproduces Kawasaki disease vasculitis using patient serum and enables rapid drug screening.
Vitamin D’s Active Form Triggers Cell Death and Rewires Purinergic Signaling in Melanoma Cells
A new study shows that calcitriol, the active form of vitamin D, kills A375 melanoma cells through mitochondrial dysfunction and ...
Innate Immune Sensors in Focus: Structural Insights into Inflammasomes and PANoptosomes Open New Therapeutic Avenues
A Cell Research review synthesizes structural and mechanistic insights into inflammasomes and PANoptosomes, revealing how innate immune sensors assemble inflammatory ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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