Kurarinol A inhibits activated stellate cells through MyD88 in preclinical study
Preclinical experiments identify kurarinol A as a candidate MyD88-targeting compound that suppresses activated hepatic stellate cells, while animal benefits were ...
Tag: NF-κB
Isorhoifolin Shields Rat Livers from Cadmium Toxicity by Taming Inflammation
A rat study reports that the flavonoid glycoside isorhoifolin countered cadmium-induced liver injury by suppressing the TLR4/MyD88/TRAF6/NF-κB inflammatory cascade, restoring ...
Synthetic Peptide IL15.3 Calms Inflamed Immune Cells on Multiple Fronts
The synthetic antimicrobial peptide IL15.3 reduced inflammatory signaling in LPS-stimulated macrophages through coordinated transcriptional and proteomic changes, with low cytotoxicity ...
TRIM27 Protein Drives Airway Inflammation in Asthma by Destroying TRAF3
A study in mouse and human airway cell models of asthma shows that the E3 ubiquitin ligase TRIM27 promotes airway ...
TIMD4-targeted nanoparticles reduce colitis inflammation in mice
A macrophage-targeted TIMD4 peptide nanoparticle reduced inflammation and monocyte recruitment in a mouse colitis model without establishing clinical benefit in ...
Review maps shared pathways in ovarian dysfunction and type 2 diabetes
A 2026 structured narrative review identifies shared insulin-signaling, inflammatory, oxidative, energy-sensing and WNT pathway defects associated with polycystic ovary syndrome ...
Stress Hormone Receptor Emerges as Shared Master Switch Behind Chronic Inflammation
A new Frontiers in Pharmacology perspective argues that dysregulated glucocorticoid receptor signaling is a shared upstream driver of chronic inflammation ...
Surface Y RNAs Turn Monocytes into Inflammatory Amplifiers
Researchers report that Y RNAs on the surface of human monocytes bind extracellular histones and amplify TLR2/TLR4-driven inflammatory signaling, with ...
Inflammatory NF-κB Signaling Comes Alive in the Septa of Newborns with Intestinal Atresia
A study of human septal tissue from infants with type I intestinal atresia reveals markedly increased expression of NF-κB pathway ...
Apigenin, a Common Plant Flavonoid, Emerges as a Multi-Target Defender of the Aging Brain
A new review in Molecular Biology Reports details how the dietary flavonoid apigenin combats oxidative stress, neuroinflammation, mitochondrial dysfunction, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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