Brucella Protein BspJ Hijacks Host Gene Zfp740 to Dampen NF-κB Defenses in Macrophages
A new cell-culture study shows that the Brucella effector protein BspJ enters the macrophage nucleus, binds the Zfp740 promoter through ...
Tag: NF-κB
Immune checkpoint protein B7-H6 emerges as a driver and vulnerability in metastatic kidney cancer
B7-H6 expression on tumor cells and tumor-infiltrating leukocytes is linked to metastasis, lymph node spread and reduced overall survival in ...
Plant Compound Ivangustin Pins Neuroinflammation on Covalent Hit at UBE2L3 Cys86
A new study reports that ivangustin, a sesquiterpene lactone from Inula japonica, suppresses microglial NF-κB signaling by covalently modifying cysteine ...
NF-κB/Atg5 Axis Linked to Treg Dysfunction in Kidney Antibody-Mediated Rejection
A new study identifies Atg5-dependent Treg regulation as a mechanistic link between Treg dysfunction and macrophage inflammation in kidney antibody-mediated ...
Two Collagen Peptides from Pig Skin Shield Skin Cells from UV Damage
Researchers identified two porcine skin collagen peptides, FGPYGF and GPPSGGFG, that protected UVB-damaged human keratinocytes in cell culture by acting ...
Vitamin D Boost Makes Electrochemotherapy Far More Potent Against Colon Cancer Cells in Lab Study
An in vitro study reports that adding 1α,25-dihydroxyvitamin D3 to oxaliplatin-based electrochemotherapy lowered the IC50 in human colon cancer cell ...
GPNMB–SMAD4 pathway links microglial inflammation to demyelination in diabetic cognitive dysfunction
A mouse and cell study finds that hyperglycemia lowers microglial GPNMB, disrupting its binding to SMAD4 and unleashing NF-κB-driven neuroinflammation ...
CK2α kinase drives P-glycoprotein buildup that undermines tuberculosis drug treatment in macrophages
A new study reports that the kinase CK2α regulates P-glycoprotein expression in macrophages through two signaling pathways, and that combining ...
MicroRNA miR-146a-5p shows link to reduced inflammation in sepsis-related lung injury
A study in BMC Immunology reports that miR-146a-5p is decreased in sepsis-induced acute lung injury patients and suppresses the IRAK1/TRAF6/NF-κB ...
Fetuin-A Reduction with Pioglitazone Eases Brain Inflammation in Aged Rats with Liver-Related Cognitive Impairment
In a rat study, lowering the protein Fetuin-A with pioglitazone was accompanied by reduced hippocampal neuroinflammation and recovered recognition memory ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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