Rare Prion Disease VPSPr Hides Among Other Proteinopathies, Two New Cases Reveal
Two new Austrian autopsy cases of variably protease-sensitive prionopathy reveal how codon 129 genetics and overlapping proteinopathies complicate diagnosis of ...
Tag: neuropathology
Chemical Tags on Brain DNA Reveal How Alzheimer’s Risk Genes Do Their Damage
A large postmortem study identified 107 brain DNA methylation sites linked to Alzheimer's pathology and showed that methylation partially mediates ...
Autopsy Study Reveals Amyloid Plaques Explain Alzheimer’s Gene Risk But Not Women’s Tau Burden
A landmark autopsy study of 2,550 brains shows APOE-ε4 drives medial temporal tau through amyloid-β while women's tau burden persists ...
AI Maps the Hidden Diversity of Amyloid Plaques Across the Alzheimer’s Brain
Using machine learning on tissue from 84 Alzheimer's disease cases, researchers have mapped six distinct amyloid-beta plaque types across 23 ...
Beyond ALS: Misfolded SOD1 Emerges as a Shared Player in Brain Disease
A sweeping review of human neuropathological evidence shows that misfolded SOD1, long tied to familial ALS, coexists with TDP-43, tau, ...
Post-mortem MRI reveals how fetal brains first begin to form the folds of polymicrogyria
By pairing high-resolution post-mortem MRI with neuropathology in four fetuses at 21 weeks, researchers have captured the earliest stages of ...
Felix Stern: The Neurologist Who Decoded a Mysterious Pandemic and Died Forgotten
A new biographical study in the Journal of Neurology reconstructs the life, groundbreaking work on encephalitis lethargica, and tragic death ...
Old Wax Blocks, New Signals: Phosphoproteomics Adds a Functional Layer to Brain Tumor Diagnostics
Researchers have shown that routine formalin-fixed paraffin-embedded brain tumor tissue yields robust proteomic and phosphoproteomic profiles that recover EGFR-associated signaling ...
AI Tumor Classifier Proves Its Worth in 516 Tough Brain Cancer Cases
A large evaluation of the Bethesda v3 DNA methylation classifier shows robust performance in routine brain tumor diagnostics, correctly classifying ...
Neuropathology-centered approach opens new era for Alzheimer’s disease genetics
A new review argues that shifting Alzheimer's disease genetic research from clinically diagnosed cohorts to neuropathologically confirmed ones is revealing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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