Enzyme AK7 in Brain Circuit Drives Chronic Inflammatory Pain in Mice
Researchers identified adenylate kinase 7 in anterior cingulate cortex projections to the ventral tegmental area as a key driver of ...
Tag: neuronal excitability
Review Connects Metabolic Reprogramming and Epigenetics to Chemotherapy-Induced Nerve Damage
A scientific review outlines a framework linking systemic metabolic reprogramming, receptor signaling, and epigenetic modifications to the persistence of chemotherapy-induced ...
Review details Slack channel mutations in epilepsy
A 2026 review in Acta Epileptologica details how KCNT1 gene mutations alter Slack channel function, leading to various forms of ...
Senescence-Like States in Sensory Neurons May Explain Why Pain Fails to Resolve
A new mini-review proposes that durable senescence-like states in dorsal root ganglion sensory neurons may help explain why pain persists ...
Lactate Receptor HCAR1 Emerges as a Brain-Wide Tuner of Neuronal Firing
A new mini review details how the lactate receptor HCAR1 modulates neuronal firing across the brain through region-specific ion channel ...
SIK1–NR4A2 pathway linked to excitability in rat epilepsy model
Machine-learning screening and experiments in rats and cultured neurons identified SIK1 as a regulator of seizure severity and neuronal excitability ...
Electroacupuncture lowers salt-induced hypertension in mice and alters PVN excitability
In male mice with high-salt-induced hypertension, electroacupuncture at the Taichong acupoint lowered blood pressure, reduced firing in two hypothalamic pathways ...
Molecular dynamics and cell experiments identify third Kv4.3–KChIP1 interface
Molecular dynamics and electrophysiology experiments identify a salt-bridge-rich third interface that stabilizes Kv4.3–KChIP1 complexes and supports potassium-channel tetramerization.
New Insights into Brain ‘Brakes’ Linked to Disorders Unearthed from Epilepsy Patient Samples
In a groundbreaking study, researchers from UC San Diego and the University of Texas Southwestern Medical Center have unveiled the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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