Cancer Immunotherapy Unmasks Rare Myasthenia Gravis Twelve Years After Thymectomy
A case report describes pembrolizumab-induced myasthenia gravis with isolated anti-titin antibody positivity in a man twelve years after thymectomy for ...
Tag: neuromuscular junction
Scaffold Protein SH3BP2 Revealed as Key to Muscle Strength at the Neuromuscular Junction
Researchers have discovered that the scaffold protein SH3BP2, previously known for its role in immune and bone cells, is essential ...
Repurposed antimalarial drug wrapped in lactoferrin nanoparticles calms complement attack on motor nerves in ALS mice
A new preclinical study reports that atovaquone, an approved antiparasitic drug, was reformulated into lactoferrin-based nanomicelles that crossed into the ...
Silencing SLITRK2 Rescues Damaged Nerve-Muscle Connections in FUS-ALS Motor Neurons
Researchers found that reducing SLITRK2 levels in human stem cell-derived FUS-ALS motor neurons restores axonal health and neuromuscular junction signaling, ...
Rapsyn Overexpression Restores Neuromuscular Junctions After Tourniquet Injuries
A mouse study shows that the scaffolding protein rapsyn is depleted after tourniquet-induced ischemia-reperfusion injury, shattering acetylcholine receptor clusters at ...
Fast-Acting Drug Pair Pulls Patient Back From Brink of Myasthenic Crisis
Doctors in China report the first sequential use of efgartigimod and telitacicept to rescue a 73-year-old MuSK-myasthenia gravis patient from ...
Thymectomy Works Just as Well in Older Myasthenia Gravis Patients, Study Finds
A Cleveland Clinic study of 79 patients finds that thymectomy delivers comparable safety and efficacy in older and younger patients ...
Bendable Memory Device Mimics the Body’s Nerve-Muscle Synapse
Researchers have created a flexible memristor based on hexagonal boron nitride whose synaptic strength is programmed directly by bending, mimicking ...
Gene Silencing of Complement C3 Shields Nerve-Muscle Junctions in Myasthenia Gravis Rats
Silencing hepatic C3 with GalNAc-targeted siRNA nearly eliminated plasma complement, preserved acetylcholine receptors, and reduced muscle weakness in a rat ...
When Muscle’s Hidden Helpers Die, Inflammation Devours Muscle From Within
New research shows that killing muscle-resident fibro-adipogenic progenitors triggers rapid atrophy not through loss of their support functions but through ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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