Sleep Loss Sabotages the Brain’s Power Grid, but a Single Protein May Restore It
A new mouse study shows that the protein APPL1 protects the sleep-deprived brain by restoring mitochondrial dynamics through the Rab32 ...
Tag: neuroinflammation
New Dementia Score Spots Treatable Rapid Decline Before It Is Too Late
A refined eight-point bedside score, the modified STAM3mP, validated in Dutch and American cohorts, detects treatable causes of rapidly progressive ...
Falling Levels of Immune Protein sCD30 in Spinal Fluid Track Huntington’s Disease Progression
A Swedish study confirms that the immune protein TNFRSF8 (sCD30) is halved in the cerebrospinal fluid of Huntington's disease gene ...
Brain Protein ATIP Linked to Lower Amyloid Burden in Alzheimer’s Disease
Researchers have found that higher levels of the ATIP protein in postmortem brains of older adults with Alzheimer's disease are ...
Histamine Signals Through H1 Receptors to Steer Microglia in Tic-Like Behavior Study
A new mouse study links reduced histamine signaling through H1 receptors to microglial activation and tic-like behaviors, with antihistamine exposure ...
Free Water Imaging in Parkinson’s Disease Demands Methodological Nuance, Study Argues
Researchers argue that free water imaging in Parkinson's disease produces method-dependent results that resist simple binary interpretation.
Obesity’s Toll on the Brain: How Midlife Weight Drives Cognitive Decline and Dementia Risk
A comprehensive review in Nature Reviews Neurology details how obesity damages the hypothalamus, hippocampus and cerebrovasculature to drive cognitive decline, ...
Lactate Signals and RNA Tags May Shape Post-Hemorrhage Depression, Review Proposes
A new review proposes that histone lactylation and m6A RNA methylation may link acute brain hemorrhage to long-term depression, anxiety, ...
Blood Proteins Reveal Distinct Immune Signatures of Alzheimer’s Impairment and Shrinkage of the Hippocampus
A study of 506 ADNI participants finds that plasma complement–acute-phase protein signatures track cognitive and functional impairment while endothelial-associated signatures ...
AMPA Receptor Blockers Show Promise for Brain Injury Recovery in Animal Studies
A new systematic review and meta-analysis of eleven animal studies finds that AMPA receptor antagonists improve neurological and cognitive outcomes ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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