Designed From Scratch: Microproteins Take Aim at Brain Disease
De novo designed microproteins, built computationally to bind toxic amyloid fibrils and restore mitochondrial function, are emerging as promising candidates ...
Tag: neurodegenerative diseases
Migrasomes Can Drive or Protect the Brain Depending on Context, Review Finds
A new review proposes that migrasomes in the central nervous system act as either pathogenic drivers or protective factors depending ...
Plant Phenolic Compounds Show Promise Against Disease, but Human Evidence Lags
A new review in Discover Molecules synthesizes the chemistry, limited bioavailability, and gut-brain interactions of plant phenolic compounds, cautioning that ...
Misfolded Proteins, Inflammasomes and the Spreading of ASC Specks in Neurodegeneration
A new review outlines how misfolded protein aggregates activate the NLRP3 inflammasome and how prion-like ASC specks may shape neurodegenerative ...
NF-κB1 Emerges as a Context-Dependent Switch in Neurodegenerative Disease
A new review argues that the NF-κB1 subunit's p105 and p50 proteins act as context-dependent regulators of neuronal survival and ...
Retuning Synaptic Dynamics Restores Memory Signals in Alzheimer’s Model
A computational model of Alzheimer's disease shows that adjusting short-term synaptic facilitation time constants can restore memory engram selectivity and ...
Plant Compound Cardamonin Shields Neurons by Calming Overactive Brain Immune Cells
A new study shows the natural chalcone cardamonin calms LPS-activated microglia by suppressing the EGFR/PI3K/AKT1/ERK/NF-kappaB signaling axis, indirectly protecting SH-SY5Y ...
Single ubiquitin tags on non-histone proteins shape health and disease
A comprehensive review in Cellular and Molecular Life Sciences maps how single ubiquitin marks on non-histone proteins regulate DNA repair, ...
Most Bulgarian Patients With Chronic Pain and Neurodegenerative Disease Would Try CBD If Doctors Recommended It
A survey of 55 Bulgarian patients found that 85.5 percent would use cannabidiol if recommended by a healthcare professional, despite ...
Sample-Preparation Workflow Improves Plasma and CSF Proteomics
A new cost-effective workflow improves proteomic analysis of plasma and cerebrospinal fluid by optimizing protein depletion and digestion for high-throughput ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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