Plant Phenolic Compounds Show Promise Against Disease, but Human Evidence Lags
A new review in Discover Molecules synthesizes the chemistry, limited bioavailability, and gut-brain interactions of plant phenolic compounds, cautioning that ...
Tag: neurodegenerative diseases
Misfolded Proteins, Inflammasomes and the Spreading of ASC Specks in Neurodegeneration
A new review outlines how misfolded protein aggregates activate the NLRP3 inflammasome and how prion-like ASC specks may shape neurodegenerative ...
NF-κB1 Emerges as a Context-Dependent Switch in Neurodegenerative Disease
A new review argues that the NF-κB1 subunit's p105 and p50 proteins act as context-dependent regulators of neuronal survival and ...
Retuning Synaptic Dynamics Restores Memory Signals in Alzheimer’s Model
A computational model of Alzheimer's disease shows that adjusting short-term synaptic facilitation time constants can restore memory engram selectivity and ...
Plant Compound Cardamonin Shields Neurons by Calming Overactive Brain Immune Cells
A new study shows the natural chalcone cardamonin calms LPS-activated microglia by suppressing the EGFR/PI3K/AKT1/ERK/NF-kappaB signaling axis, indirectly protecting SH-SY5Y ...
Single ubiquitin tags on non-histone proteins shape health and disease
A comprehensive review in Cellular and Molecular Life Sciences maps how single ubiquitin marks on non-histone proteins regulate DNA repair, ...
Most Bulgarian Patients With Chronic Pain and Neurodegenerative Disease Would Try CBD If Doctors Recommended It
A survey of 55 Bulgarian patients found that 85.5 percent would use cannabidiol if recommended by a healthcare professional, despite ...
Sample-Preparation Workflow Improves Plasma and CSF Proteomics
A new cost-effective workflow improves proteomic analysis of plasma and cerebrospinal fluid by optimizing protein depletion and digestion for high-throughput ...
Why siRNA Delivery Keeps Failing in Neurodegenerative Diseases
A new review argues that the bottleneck for RNAi therapies in Alzheimer's, Parkinson's and Huntington's disease is not gene silencing ...
AI Meets the Mind: How Health Data Science Is Rewiring Neuroscience and Psychology
Artificial intelligence is quietly transforming two of the most intimate fields of medicine: neuroscience and psychology. A new editorial published ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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