Observational genome study links eight processes to most prostate cancer DNA damage
An observational analysis of 959 prostate tumours from 1,001 men found that eight cellular processes account for 85% of DNA ...
Tag: mutational signatures
Alzheimer’s tetraploid neurons show enriched somatic single nucleotide variants
A six-brain sequencing study found that Alzheimer’s-associated tetraploid neurons carried excess low-frequency somatic single nucleotide variants, with enrichment for T>C ...
Multi-Omics Map of Chinese Cervical Cancer Patients Reveals New Drug Targets
An integrated multi-omics study of 112 Chinese cervical cancer patients reveals key driver mutations, immune phenotypes, and promising therapeutic targets.
New Browser-Based Toolkit Runs Cancer Mutational Signature Analysis Without Installing a Thing
A new open-source JavaScript toolkit called mSigSDK brings multi-tool mutational signature analysis, privacy-preserving local computation, and reproducible reporting directly into ...
Space Radiation Leaves Distinct Mutational Fingerprints in Mouse Liver Tumors
Whole genome sequencing of liver tumors in outbred mice reveals distinct mutational fingerprints of heavy-ion and gamma-ray radiation, including frequent ...
Mutational Fingerprints Reveal the Hidden Forces Driving Prostate Cancer
A new Nature study integrates multiple classes of genomic mutations to define the distinct mutational processes that shape prostate cancer ...
Cancer Therapy Reshapes Mutation Competition in Healthy Esophageal Tissue
New research shows that cancer therapy selects for preexisting drug-resistant and druggable mutant clones in normal esophageal tissue, reshaping the ...
Reading the Evolutionary History of Cancer Written in Tumour Genomes
A Nature Reviews Cancer review argues that population genetics offers the mathematical framework needed to turn tumour genome sequencing data ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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