Chiral virus-like nanoparticles improve antibiotic delivery in mouse meningitis models
An L-alanine-functionalized, virus-like mesoporous silica carrier improved antibiotic delivery and therapeutic outcomes in mouse models of bacterial meningitis.
Tag: mouse models
SWAP70 promotes liver cancer growth through CPT1A-dependent fatty acid oxidation
Cell, tissue and mouse experiments link elevated SWAP70 to advanced human liver tumors and show that it supports hepatocellular carcinoma ...
IKKε deficiency reduces osteoarthritis pain and synovitis in mice
IKKε deficiency reduced pain-related behavior and synovitis in mouse osteoarthritis models without producing a statistically significant reduction in cartilage degeneration.
Scientists Map the Hidden Cellular Wiring That Drives Rheumatoid Arthritis Joint Destruction
A cross-species single-cell and spatial transcriptomics study reveals a conserved Notch/AP-1 to fibronectin and thrombospondin signaling axis operating in a ...
A Single Nicotinic Receptor Gene Shapes Empathy and Aggression in Mice
New research shows that two mutations of the α5 nicotinic receptor gene produce opposing empathy-related behaviors in mice, mirroring distinct ...
Missing Immune Receptor Silences the Ear’s Nerve Cells and Drives Hearing Loss
A new study shows that the chemokine receptor CXCR2, long associated with inflammation, is essential for hearing because its loss ...
Scientists Discover a Molecular Repulsion System That Keeps Blood Pressure in Check
A new Nature Communications study shows that the axonal guidance molecule EphrinA4 in arterial smooth muscle cells repels sympathetic nerves ...
Hormone Meets Channel: Leptin Emerges as a Bridge Between Brain Development and Metabolism
New research in iScience shows that the hormone leptin, the potassium channel Kcnb1, and integrins form a tripartite brain complex ...
Stress Silences an RNA-Binding Protein in the Hippocampus, Revealing a New Antidepressant Pathway
A new mouse study shows that the RNA-binding protein TIA1 in ventral hippocampal CA1 excitatory neurons protects against depressive-like behaviors ...
Bacterial Biofilms May Trigger the Autoantibodies Behind Lupus Kidney Damage
New research in mice shows that curli amyloid fibers from Salmonella and E. coli biofilms can drive the production of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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