AI-Designed Protein Binders Face Real-World Test in Landmark CAR T Cell Competition
A crowdsourced competition called Bits to Binders tested 12,000 AI-designed minibinders as CAR T cell recognition domains, revealing both the ...
Tag: Molecular Systems Biology
Genetic Barcodes Reveal What Tumor Biopsies Miss
By tagging breast cancer clones with unique genetic barcodes, researchers have quantified exactly how much tumor diversity needle biopsies and ...
Pooled AlphaFold3 screening maps a bacterium’s protein interactions 100 times faster
Researchers have devised a pooled AlphaFold3 screening strategy that cuts the number of computational jobs needed to map an entire ...
Old Antabuse Drug Turns Breast Cancer Resistance Against Itself
Researchers report that the repurposed alcoholism drug disulfiram exploits a collateral vulnerability in chemotherapy-resistant ER+ breast cancer cells, and that ...
PCR-Only Protein Engineering Platform Skips Bacteria and Builds Better Biosensors in a Day
A new method called MIDAS assembles and screens hundreds of protein variants directly in mammalian cells without any microbial cloning ...
New AI Framework Reads and Rewrites Cell Trajectories Inside Living Tissue
A new deep generative and agent-based framework called veloAgent integrates spatial context into RNA velocity analysis, producing anatomically consistent cell ...
Massive Protein Interaction Map Reveals How Muscles Fall Silent to Insulin
Researchers have built the first quantitative interactome maps of insulin-resistant skeletal muscle, revealing that protein network rewiring — particularly around ...
E. coli cells race to rebuild their proteins in the first hours of starvation
New single-cell microscopy reveals that E. coli immediately halts growth when carbon runs out and uses the first hours of ...
Kinase Inhibitors Trigger Surprising Non-Catalytic Effects by Displacing Autoinhibitory Domains
A multimodal proteomics study shows that ATP-competitive kinase inhibitors displace autoinhibitory domains, driving unexpected non-catalytic functions relevant to drug development.
Engineered E. coli swarms record chemical and light inputs in visible patterns
Engineered E. coli strains record chemical and optical inputs in binary or analog swarming patterns that machine-learning models can decode ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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