NAD+ Collapse Drives Senescent CD8+ T Cells That Worsen Ulcerative Colitis
A new study in Aging Cell shows that NAD+ metabolic collapse drives senescent CD8+ T cells to fuel ulcerative colitis ...
Tag: mitochondrial dysfunction
Stem Cell Transplant Cured a Girl’s Leukemia but Left Her Friedreich Ataxia Unchanged
A decade-long case report shows that allogeneic stem cell transplantation cured a Friedreich's ataxia patient's leukemia and normalized her blood ...
Aging Immune Cells May Undermine a Promising Cancer Therapy, Review Warns
A new review argues that immune aging and manufacturing stress, not just tumor biology, explain why gamma-delta T cell cancer ...
Heart Cells Have a 24-Hour Molecular Switch That Turns Sleep Apnea Damage On
A new study finds that intermittent hypoxia triggers a precise 24-hour threshold of microRNA remodeling in heart cells, with miR-146b-5p ...
DNA Repair Protein APEX1 Emerges as Key Guardian of Egg Cell Quality
New research shows that the DNA repair and redox-signaling protein APEX1 protects oocyte quality by sustaining mitophagy and suppressing iron-dependent ...
Mitochondrial DNA Methylation Unchanged in Down Syndrome, Study Finds
The first study to examine mitochondrial D-loop methylation in Down syndrome finds no significant differences in methylation or mitochondrial DNA ...
Copper Overload Pushes Cells Toward Death in Wilson Disease
A new review in Cell Death & Discovery links copper overload, mitochondrial failure and regulated cell death pathways including cuproptosis ...
How Microglial Metabolism and Mitochondria Drive Brain Damage After Stroke
A new review integrates mitochondrial quality control, metabolic reprogramming, and NLRP3 inflammasome activation into a single framework explaining how microglia ...
Intermittent Fasting Shows Early Promise Against Huntington’s Disease in First Human Trial
A 12-week pilot trial found that an eight-hour time-restricted eating window was feasible, well tolerated, and associated with favorable clinical ...
Graph Diffusion Extends Metabolomic Signals to Unmeasured Metabolites
Researchers have developed a network propagation method that diffuses statistical signals across a bipartite metabolite–reaction graph, extending metabolomic data exploration ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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