Mitochondrial Gene Signature and NT5DC3 Predict Outcomes in Nasopharyngeal Carcinoma
A new mitochondria-related gene signature and NT5DC3 analysis identify disease prognosis and immunosuppressive traits in nasopharyngeal carcinoma.
Tag: mitochondria
SRP68 Loss Disrupts ER-Mitochondrial Links in Mouse Spermatogenesis
A new study shows that SRP68 is essential for mouse spermatogenesis, as its loss disrupts ER-mitochondrial contacts and leads to ...
Amyloid beta disrupts mitochondrial ceramide signals and lysosomal stress in Alzheimer’s models
A study in EMBO Reports reports that mitochondrial APP and Aβ40 are associated with reduced CerS1/C18-ceramide accumulation and mitophagy readouts ...
Antifungal Drug Butoconazole Suppresses Liver Cancer by Disrupting Cellular Energy Metabolism
Researchers have identified the antifungal drug butoconazole as a dual inhibitor of energy metabolism that suppresses liver cancer growth in ...
SAMM50 Protein Elevation Signals Unfavorable Prognosis and Aggressive Progression in Hepatocellular Carcinoma
Researchers have identified mitochondrial protein SAMM50 as an independent prognostic factor and driver of aggressive tumor behavior in hepatocellular carcinoma.
Cells juggle two routes to make DNA building blocks, review finds
A Nature Metabolism review examines how cells balance de novo synthesis and salvage of nucleotides across tissues, immunity and cancer.
Male mice pay a heavier metabolic price for a fatty diet
A 40-week mouse study found that males on a high-fat, high-cholesterol diet developed more severe muscle atrophy than females, linked ...
Notch ligand DLL1 shields ovarian cancer cells from ferroptosis, fueling cisplatin resistance
A preclinical study reports that the Notch ligand DLL1 activates an Nrf2/GPX4 antioxidant axis that suppresses ferroptosis and weakens cisplatin's ...
Superoxide in injured mouse lungs imaged directly by low-frequency EPR
Low-frequency EPR imaging of excised mouse lungs reveals that blood superoxide does not always reflect lung redox status in acute ...
Perforin Kills Cancer Cells Alone, Without Granzymes, Study Finds
New research shows the immune protein perforin can kill tumor cells on its own by triggering iron-dependent ferroptosis, even when ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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