Scientists uncover how tobacco rewires head and neck cancer metabolism through a single mucin molecule
New research reveals that tobacco carcinogens lift a GATA4-mediated brake on the mucin MUC5B, driving fatty acid metabolism and immune ...
Tag: metabolic reprogramming
Diabetes and Cancer Feed Each Other: How Epigenetics Explains the Deadly Two-Way Street
A comprehensive review in Diabetes Therapy maps the bidirectional relationship between diabetes and cancer, positioning epigenetic dysregulation as the molecular ...
Silencing a Fat-Making Master Switch Pushes Pancreatic Cancer Cells Toward Self-Destruction
New research links elevated SREBF1 expression to lipid metabolism signatures in pancreatic cancer and shows that silencing the gene triggers ...
Heart Cell Metabolism Switch Reactivates Dormant Repair After Heart Attack
Researchers at Sanford Burnham Prebys report that temporarily blocking the metabolic enzyme succinate dehydrogenase triggers an epigenetic switch in mouse ...
Lactate Marks on Histones Drive Wilms Tumor Growth Through a Self-Reinforcing Genetic Loop
New research reveals that lactate-driven histone H3K18 lactylation activates a PSRC1/AKT/HIF-1α positive feedback loop that propels the malignant progression of ...
How Exercise Reprograms Glucose Metabolism to Fight Osteoporosis
A new review reveals that exercise protects against osteoporosis by reprogramming how bone cells burn glucose, linking glycolysis, lactate signaling, ...
Scientists Uncover a Sugar-Burning Switch That Drives Liver Scarring
A new Nature Communications study shows that the ubiquitin ligase PRPF19 drives hepatic stellate cell activation and liver fibrosis by ...
Fat-Filled Droplets Power the Deadliest Childhood Brain Tumours
New research shows that high-risk Group 3 and Group 4 medulloblastoma cells accumulate cholesterol ester-rich lipid droplets that support energy ...
Cholesterol’s Hidden Geography: How Tumor Neighborhoods Fuel Resistant Prostate Cancer
A paired spatial multi-omics study of prostate cancer reveals that rising cholesterol during therapy tracks with castration resistance, as import-dominant ...
Viral protein hijacks a metabolic enzyme to drive Kaposi’s sarcoma spread
Researchers have shown that the KSHV protein vIRF3 binds and activates the metabolic enzyme PKM2, raising acetyl-CoA levels that drive ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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