Hidden mitochondrial lactate pathway keeps the heart fueled under stress
Researchers have discovered that the heart can oxidize glucose through a mitochondrial lactate import pathway centered on the transporter MCT1, ...
Tag: metabolic flexibility
Scientists Propose a Framework to Test How Menopause Changes Lactate Metabolism During Exercise
A new Frontiers in Physiology Mini Review finds no study has directly measured lactate flux during natural perimenopause and proposes ...
Serine and Glycine Scarcity Drives Pancreatic Cancer Cells Toward Stem-like, Invasive Behavior
Adapting to serine and glycine scarcity rewires mitochondrial metabolism in pancreatic cancer cells and increases their cancer stem cell frequency, ...
Glutamine-aspartate tradeoff shapes cancer cell growth and flexibility
A systematic study of 54 cancer cell lines reveals a tissue-linked tradeoff between using glutamine or aspartate for glutamate synthesis, ...
Body Clock Gene NPAS2 Shields the Diabetic Heart by Keeping Mitochondria Fueled
A new study shows that the circadian clock protein NPAS2 protects the diabetic heart by preserving pyruvate dehydrogenase activity and ...
Fungi That Abandon Biofilms Gain a Hidden Edge Inside the Human Body
A new PLOS Biology study of fluconazole-resistant Candida parapsilosis outbreak isolates shows that strains with reduced biofilm production gain metabolic ...
Molecular switch in brown fat syncs fat-burning with body clock, diet and cold
Researchers at the University of Copenhagen have identified the mitochondrial protein SLC25A34 as a molecular switch that links the body ...
SGLT2 Inhibitors Found to Repair Heart Metabolism Through Coenzyme A Pathway
New evidence shows SGLT2 inhibitors protect the failing heart by directly activating PANK1 to restore coenzyme A biosynthesis and myocardial ...
Novel pyruvate tracer reveals dichloroacetate’s distinct effects on muscle metabolism
For decades, peering into the energy factories of a living muscle meant settling for indirect readings—measurements that hinted at what ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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