Ketoprofen–thiazolidinone hybrids reduce inflammation in mouse paw edema
A study of synthesized ketoprofen–thiazolidin-4-one hybrids found that AR3 reduced mouse paw edema more consistently than ketoprofen at later time ...
Tag: medicinal chemistry
Robots and Light Power KAIST’s Round-the-Clock Unmanned Drug Synthesis Platform
KAIST chemists have built an automated platform that combines robots, continuous-flow chemistry and visible light to synthesize drug candidate compounds ...
Oxadiazole compound shows potent selectivity against oligodendroglioma cells
Researchers have synthesized a series of 1,3,4-oxadiazole derivatives and evaluated their anticancer potential against HS683 human oligodendroglioma cells, identifying one ...
Quinoline scaffolds drive new wave of antiprotozoal drug discovery
The burden of protozoan disease is not evenly distributed across the globe, and this asymmetry shapes nearly every aspect of ...
How Kelly Chibale Redrew the Map of Global Drug Discovery From Africa
A new Frontiers perspective chronicles how Professor Kelly Chibale built Africa's first fully integrated drug discovery centre at the University ...
Neural Network Sharpens Early Drug Discovery With 95.9% Accuracy in Predicting Painkilling Compounds
Researchers in Algeria have built an optimized neural network that predicts the analgesic activity of drug-like molecules with 95.9 percent ...
New Diamine Compounds Show Potent Activity Against Multiple Leishmania Species
A second-generation library of N,N′-disubstituted aliphatic diamines shows potent, selective activity against multiple Leishmania species, with compounds 12a, 12m, and ...
Massive Molecular Screen Targets a Fatal Weak Point in Tuberculosis Transcription Machinery
Researchers screened more than 87,000 compounds against the essential interaction between the tuberculosis bacterium's RNA polymerase and the transcription factor ...
Scaffold Hopping Yields New Histamine H3 and H4 Receptor Ligands
Medicinal chemists... The histamine receptor family offers a striking example of how a single small molecule can orchestrate profoundly different ...
Computational Screening Points to Two Quinoline Candidates Against Tuberculosis and Resistant Infections
Computational screening of four halogenated quinoline derivatives identifies QNL1 and QNL3 as promising oral drug candidates against tuberculosis, E. coli, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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