AI Chemist Learns to Edit Molecules Into Makeable Medicines
Researchers at Peking University have developed SynCraft, a framework that uses large language models to predict precise atom-level edit sequences ...
Tag: medicinal chemistry
Engineered Cytisine Derivative Disrupts Redox Balance to Kill Lung Cancer Cells
Researchers engineered a thiourea-bridged cytisine derivative, YU-C-ThioU-9, that overwhelms the antioxidant defenses of lung cancer cells by disrupting Nrf2-Keap1 and ...
Electricity Powers a Greener Route to Deuterium-Labeled Antioxidant Molecules
Chemists have developed an electrochemical three-component cascade that installs trideuteromethylthio groups onto enaminones, yielding compounds that can protect cells from ...
AI-designed molecules plus expert chemistry yield nanomolar tyrosinase inhibitors
A reinforcement learning model that designs synthetically accessible molecules from scratch, combined with expert medicinal chemistry, produced a tyrosinase inhibitor ...
Nickel Catalyst Alkylates Drug-Like Rings at Mild Temperatures
Scripps Research chemists have developed a nickel-catalysed, sulfonylhydrazide-based C–H alkylation that attaches alkyl groups to arenes and heteroarenes below 50 ...
Copper Catalyst Stays in Balance: KAIST Ligand Strategy Unlocks Stubborn Alkyl Chlorides for Drug-Like Molecules
KAIST chemists used a cyclopropenimine ligand to balance radical generation and copper catalyst regeneration, enabling difficult radical cyclizations of tertiary ...
PROTACs Move From Lab Concept to Clinical Reality in Targeted Protein Degradation
A new comprehensive review in Discover Chemistry details how PROTACs have evolved from a mechanistic concept into clinically advanced degraders ...
Phosphorus-Powered Pyrazoles Show Potent Antimicrobial Activity Against E. coli
Chemists have synthesized a series of N-phosphorylated 5-aminopyrazoles that show promising antibacterial activity, with one thiophosphorylated derivative approaching the potency ...
Chemists forge chiral piperidine mimics in a single asymmetric leap
Chemists at Chongqing University report the first catalytic asymmetric synthesis of chiral 2-azaspiroheptanes, delivering a powerful new piperidine bioisostere for ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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