Gudan Wan reduced liver injury in mouse model of MASH
A preclinical mouse study found that Gudan Wan reduced liver injury, inflammation and fibrosis while altering autophagy- and apoptosis-related proteins, ...
Tag: MASH
Type 2 diabetes fatty liver may begin in dysfunctional adipose tissue
A 2026 narrative review proposes that MASH in type 2 diabetes often begins with dysfunctional adipose tissue, which disrupts lipid ...
Gut microbiome may influence variable responses to MASH therapies
A review finds that microbial metabolites may influence variable responses to MASH therapies, but direct clinical evidence linking gut microbial ...
Fatty liver disease is not just a liver problem: how gut microbes, genes and metabolism collide
A new review explains how gut microbes, host genetics and metabolic dysfunction interact to drive MASLD and shape emerging therapies.
Fat Rewrites the Rules of Liver Cancer Across Every Disease Stage
A new review proposes that lipid metabolism plays fundamentally different roles at each stage of fatty liver disease progression to ...
Excess Salt May Trigger Fatty Liver Disease in Lean People Through a Distinct Biological Pathway
A Duke-NUS pre-clinical study has created the first diet-induced mouse model of lean MASH, showing that excess dietary salt can ...
Anti-ageing drug combo clears senescent cells and reverses liver scarring in first randomized trial
A phase-2 randomized trial shows intermittent dasatinib plus quercetin significantly improved liver fibrosis and resolved MASH in nearly half of ...
Bile Acid Receptors FXR and TGR5 Emerge as Master Switches in Liver Disease
A comprehensive new review details how the bile acid receptors FXR and TGR5 regulate fat metabolism, inflammation, fibrosis, and liver ...
First-in-Human PET Tracer Tracks Active Fibrosis With Safe Radiation Dose
A first-in-human study shows the PDGFRβ-targeting PET tracer Ga-ATH001 delivers a safe radiation dose and highlights active liver fibrosis in ...
From Digestion to Drug Design: Bile Acids Emerge as a Powerful Therapeutic Platform
A new review charts how bile acids have evolved from simple digestive surfactants into a versatile platform for receptor agonists, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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