First-in-Human PET Tracer Tracks Active Fibrosis With Safe Radiation Dose
A first-in-human study shows the PDGFRβ-targeting PET tracer Ga-ATH001 delivers a safe radiation dose and highlights active liver fibrosis in ...
Tag: MASH
From Digestion to Drug Design: Bile Acids Emerge as a Powerful Therapeutic Platform
A new review charts how bile acids have evolved from simple digestive surfactants into a versatile platform for receptor agonists, ...
A single ubiquitin enzyme emerges as a master switch between liver repair and liver destruction in MASH
Researchers report that loss of the K63-linked ubiquitination enzyme UBE2N in hepatocytes drives metabolic dysfunction-associated steatohepatitis by blocking p62-mediated mitophagy ...
Microbial Natural Products Yield Promising Dual Drug Candidates for Diabetes and Liver Disease
A computational screen of more than 36,000 microbial natural products identified six potential GSK-3β inhibitors as candidate dual therapeutics for ...
Which Fat You Eat May Steer Immune Cells That Drive Liver Scarring
New research shows that individual fatty acid species differentially reprogram macrophage polarization and oxidative stress, indirectly modulating antioxidant signaling in ...
Liver’s Master MicroRNA: How miR-122 Shapes Fatty Liver Disease, Hepatitis and Cancer
A comprehensive review shows that microRNA-122 acts as both a master regulator of liver biology and a sensitive, context-dependent biomarker ...
Macrophage Gadd45b Emerges as Key Driver of Inflammation-Linked Liver Cancer
A refined experimental model of metabolic dysfunction-associated steatohepatitis-driven liver cancer identifies macrophage Gadd45b as a central regulator of inflammation-driven tumor ...
Ubiquitin Enzyme UBE2N Emerges as Master Switch Between Liver Repair and Damage
A new Nature Metabolism study identifies the ubiquitin-conjugating enzyme UBE2N as the molecular switch that determines whether hepatocytes undergo protective ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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