Hidden RNA Cleanup Role of Immune Sensor MDA5 Shields Lungs from Fibrosis
Researchers found that the immune sensor MDA5 moves to the cell surface during lung injury to clear extracellular RNA, and ...
Tag: macrophages
Single-cell atlas maps how topical imiquimod reshapes the spleen in a lupus-like mouse model
A new single-cell RNA sequencing study maps how topical imiquimod remodels splenic immune cells in a lupus-like mouse model, revealing ...
CK2α kinase drives P-glycoprotein buildup that undermines tuberculosis drug treatment in macrophages
A new study reports that the kinase CK2α regulates P-glycoprotein expression in macrophages through two signaling pathways, and that combining ...
Monocytes in rheumatoid and psoriatic arthritis follow distinct inflammatory paths
A new study finds that CD14-positive monocytes from rheumatoid arthritis and psoriatic arthritis patients show distinct inflammatory, metabolic, epigenetic and ...
Drug-loaded hydrogel triggers immune cells to rebuild bone in defects
A collagen hydrogel releasing a T cell-inducing drug enhanced bone regeneration in a rodent skull defect model.
Infiltrating Macrophages Help Repair the Retina After Ischemic Injury, Mouse Study Finds
A mouse study finds that infiltrating monocyte-derived macrophages support blood-retinal barrier restoration and neurovascular repair after retinal ischemia-reperfusion injury, with ...
Newly identified soluble SIRPα ligand SERPINA3 dampens inflammation and shields tumors
Researchers report that SERPINA3 acts as a soluble SIRPα ligand that suppresses immune cells, easing inflammatory disease models while helping ...
AI pathology scoring flags longer survival on pembrolizumab in metastatic triple-negative breast cancer
An AI-based digital pathology assessment of PD-L1 identified metastatic triple-negative breast cancer patients with longer progression-free survival on pembrolizumab in ...
How Metabolic Reprogramming May Drive Refractory Pneumonia in Children
A new review proposes an immunometabolic framework for paediatric refractory Mycoplasma pneumoniae pneumonia, while stressing that most supporting evidence remains ...
Serotonin Receptor in Brain Macrophages Boosts Debris Clearance After Stroke
A mouse and human study identifies an Htr2b-positive macrophage subset in the ischemic brain whose serotonin-driven lysosomal activity supports debris ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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