Aging Muscle Fails Through Broken Cell-to-Cell Communication, Review Finds
A new review in Aging Cell argues that skeletal muscle aging is driven by the breakdown of multicellular communication networks ...
Tag: macrophages
Single-Cell Atlas Reveals Macrophages That May Drive Chronic Kidney Transplant Rejection
A single-cell multi-omic study of transplanted mouse kidneys identifies SPP1-positive macrophages and a CEBPβ-centered regulatory program as candidate drivers of ...
The Don’t Eat Me Signal: How CD47 Shapes Cell Clearance in Cancer, Heart Disease and the Brain
A new review details how the CD47 don't eat me signal regulates efferocytosis and shapes disease outcomes in cancer, atherosclerosis ...
Single-Cell Atlas Reveals How Goat Embryos Turn Intersex, Offering Clues to Human Sex Development
Single-cell RNA sequencing of dairy goat embryos has revealed how stromal and epithelial cells steer gonad development and which genes, ...
Rapamycin Reprograms the Aging Immune System to Cool Inflamed Arteries in Mice
Rapamycin treatment reprogrammed the aging immune system in atherosclerotic mice, reducing plaque macrophages and neutrophils, expanding regulatory T cells, and ...
Safer Macrophage-Based Immunotherapy Combo Shows Promise Against Ewing Sarcoma
Researchers have replaced the toxic components of a macrophage-directed immunotherapy for Ewing sarcoma with cyclophosphamide and the erythrocyte-sparing antibody lemzoparlimab, ...
Parkinson’s Protein Alpha-Synuclein Drives Clogged Arteries by Jamming Cellular Recycling
New research shows that alpha-synuclein, best known for its role in Parkinson's disease, enters macrophages through the protein FLOT1, blocks ...
One Stress Gene in Immune Cells May Explain Why COPD and Clogged Arteries Go Hand in Hand
A combined single-cell and genetic analysis identifies the stress-response gene HSPA1B as a cell-type-specific molecular bridge between COPD and atherosclerosis.
African swine fever virus reshapes host genome architecture within hours of infection
New research shows that African swine fever virus extensively reorganizes host chromatin architecture and RNA polymerase II activity within hours ...
Cholesterol-Hungry Immune Cells May Decide Survival in Head and Neck Cancer
A multi-omics study finds that LDL cholesterol metabolism reshapes macrophages and tumor cells in head and neck squamous cell carcinoma, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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