Sugar Switch on Immune Cells Could Push Macrophages Back Into Cancer-Fighting Mode
Researchers found that blocking the enzyme ST6GAL1 reverses a sugar-linkage switch on macrophages, restoring tumor-fighting behavior and slowing colorectal cancer ...
Tag: macrophages
Scientists Reveal the Cellular Dialogue That Scars Nasal Polyps From Within
A new study integrates single-cell transcriptomics with human tissue and mouse model validation to show that TGF-beta/Smad-driven dialogue between epithelial ...
Immune Protein CD37 Blocks Leg Muscle Healing in Artery Disease
New research shows that the immune surface protein CD37 drives inflammatory macrophage activity that impairs blood vessel regrowth and muscle ...
Transplant Drug Rewires Prostate Tissue in Two Distinct Phases, Rat Study Finds
A new rat study shows the immunosuppressant mycophenolate mofetil dismantles prostate stromal fibers in two timed phases, reshaping collagen, immune ...
Immune Enzyme PTPN2 Emerges as Master Switch in Sepsis Inflammation
McGill University researchers have identified the enzyme PTPN2 as a key regulator of non-canonical inflammasome activation, revealing how it shapes ...
Engineered Macrophages Emerge as a New Frontier in Cell Therapy for Solid Tumors
A new review details how chimeric antigen receptor-engineered macrophages are overcoming the barriers that stalled CAR-T therapy in solid tumors, ...
Mitochondrial Quality Genes Yield Seven-Gene Prognostic Signature for Breast Cancer
Researchers report that mitochondrial quality regulation gene activity defines two prognostically distinct breast cancer subtypes and supports a seven-gene survival ...
How a Single Amino Acid Pathway May Steer Autoimmune Disease
A new review in the Journal of Translational Medicine details how the glutamine-glutamate metabolic axis regulates immune cell fate and ...
Nanovaccine Built From Metal–Organic Frameworks Drives Tumours Into Full Retreat
A metal–organic framework nanovaccine co-delivering tumour antigens and STING agonists induced systemic tumour regression, immune memory and synergy with radiotherapy ...
A Common Amino Acid Throws a Molecular Wrench Into the Body’s Inflammation Machine
New research shows the dietary amino acid l-arginine directly binds the NLRP3 inflammasome and blocks its assembly, easing inflammatory and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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