Scientists uncover how tobacco rewires head and neck cancer metabolism through a single mucin molecule
New research reveals that tobacco carcinogens lift a GATA4-mediated brake on the mucin MUC5B, driving fatty acid metabolism and immune ...
Tag: M2 macrophages
Brain-Style NMDA Receptors Rewire Immune Cells Inside Tumors, Review Finds
A new review describes how NMDA glutamate receptors on myeloid cells drive calcium-dependent reprogramming toward immunosuppressive states, and how blocking ...
Cancer Protein TIPE Hijacks Immune Cells to Fuel Colorectal Tumor Growth
New research reveals how the tumor protein TIPE drives colorectal cancer progression by converting macrophages into tumor-supporting M2 cells through ...
Macrophage Exosomes Carry a MicroRNA That Drives Scarring in the Lung, Study Finds
Researchers report that M2 macrophage-derived exosomal miR-350-5p accelerates pulmonary fibrosis by suppressing Smad7 and amplifying TGF-beta signaling in lung fibroblasts ...
Citrus-Derived Flavonoid Didymin Shows Promise for Healing Tendon-Bone Injuries
A new mouse study shows the natural flavonoid didymin promotes tendon-bone healing by reprogramming macrophage metabolism through PPAR-mediated fatty acid ...
Sphingosine Rheostat Reemerges as an Immune Suppression Switch in Metastatic Colorectal Cancer
A large multi-omics study repositions the classic sphingosine-1-phosphate/ceramide rheostat from tumor cells to the stromal-immune compartment, linking the lipid imbalance ...
Ancient Chinese Herbal Formula Shows Promise Against Disc Degeneration
A classical Chinese herbal formula, Juanbi Tang, attenuates intervertebral disc degeneration in rats by suppressing p38MAPK/NF-κB signaling, activating Atg5-dependent autophagy, ...
OLR1 Emerges as Key Driver of Gastric Cancer Growth and Immune Evasion
A new study shows that the lipid receptor OLR1 drives gastric cancer progression by activating NF-κB signaling and polarizing macrophages ...
Newly Discovered Trypsinogen Variants Drive Immune Responses in IgG4-Related Disease
Researchers identified novel PRSS1 trypsinogen variants in IgG4-related disease tissue and linked them to M2 macrophage-driven type 2 immune responses.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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