Scientists Uncover a Sugar-Burning Switch That Drives Liver Scarring
A new Nature Communications study shows that the ubiquitin ligase PRPF19 drives hepatic stellate cell activation and liver fibrosis by ...
Tag: Liver fibrosis
Simple Blood Test Shows Promise for Detecting Liver Fibrosis in Schistosomiasis
A pilot study in Brazil found that the Enhanced Liver Fibrosis blood test rises in step with the severity of ...
Blood Sugar Control, Not Weight Loss, Reversed Liver Fibrosis Risk in Diabetic Patients
A 24-week clinical trial in patients with type 2 diabetes and fatty liver disease found that optimal glycemic control, but ...
AI Agents Learn to Find, Rerun, and Reanalyze Published Omics Data
A new agentic framework uses large language model agents with containerized tools to retrieve, re-quantify, and synthesize published omics data, ...
Anti-Inflammatory, Antioxidant-Rich Diets Linked to Longer Survival in Fatty Liver Disease
A large NHANES-based study finds that pro-inflammatory diets roughly double mortality risk in fatty liver disease while antioxidant-rich diets are ...
Copper Overload Silences a Key Liver Fat Gene, Pushing Cells Into Ferroptosis in Wilson Disease
New research shows that copper accumulation in Wilson disease shuts down the PPARα–FABP1 fat-handling axis in hepatocytes, sensitizing them to ...
Single-cell atlas of human liver pinpoints scar macrophages as drug target for fibrosis
A 649,295-cell single-cell atlas of human livers has revealed a pro-inflammatory OLR1-positive scar-associated macrophage population that expands across chronic liver ...
Blocking EP300 Rewires Scar-Associated Macrophages to Fight Acute Liver Failure
A new Nature Communications study shows that inhibiting the epigenetic enzyme EP300 restores the antibacterial function of scar-associated macrophages by ...
Anti-ageing drug combo clears senescent cells and reverses liver scarring in first randomized trial
A phase-2 randomized trial shows intermittent dasatinib plus quercetin significantly improved liver fibrosis and resolved MASH in nearly half of ...
Next-Generation Fibrate Pemafibrate Outperforms Fenofibrate in Fatty Liver Disease Trial
A 356-patient Japanese trial found the selective PPARα modulator pemafibrate reduced liver enzymes in a dose-dependent manner and preserved kidney ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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