TNFAIP3 curbs lactylation-driven DNA repair and boosts chemotherapy sensitivity in ovarian cancer
A new Cellular Oncology study reports that the tumor suppressor TNFAIP3 restrains lactylation-linked DNA damage repair and increases ovarian cancer ...
Tag: lactylation
Metabolic Protein Tags Emerge as Key Players in Disc Degeneration
A new review maps how metabolite-driven protein modifications such as lactylation, O-GlcNAcylation and succinylation may link the disc's harsh metabolic ...
Lactate tags EZH2 protein to worsen sepsis lung injury in mice
A new study in mice and human endothelial cells shows that lactate-driven EZH2 lactylation at lysines 30 and 406 promotes ...
Metabolism, immunity and the microbiome shape the breast cancer microenvironment
A new Frontiers in Oncology Research Topic gathers six articles examining how metabolism, inflammation, immunity and the gut microbiome influence ...
Three genes tied to lactylation and lactate metabolism may flag prostate cancer recurrence risk
An integrated sequencing analysis identified MKI67, MIPEP and CCNA2 as candidate prognostic biomarkers for biochemical recurrence risk in prostate cancer.
Damaged Mitochondria and Runaway Glycolysis Reshape Immune Responses, Review Finds
A new review proposes that compensatory upregulation of fermentative glycolysis following mitochondrial dysfunction integrates and modulates the immune responses triggered ...
SIRT1 Loss Drives Tumor Growth Through NSUN2 Lactylation and Asparagine Production
A new study reports that SIRT1-mediated delactylation of NSUN2 suppresses m5C-dependent asparagine biosynthesis in hypopharyngeal squamous cell carcinoma, and that ...
Lactylation gene signature predicts outcomes in clear cell renal cell carcinoma
A machine-learning 15-gene lactylation signature predicts prognosis and drug response in clear cell renal cell carcinoma, with CCNA2 identified as ...
Lactate modification drives mitochondrial damage and fibrosis in diabetic hearts
A new study links lactate-driven protein lactylation to impaired mitochondrial cleanup and activated TGF-β1 signaling, offering a dual mechanism for ...
Lactylation links glioblastoma metabolism to progression and resistance
A 2026 review links lactate-driven protein lactylation to glioblastoma growth, stemness, immune escape and treatment resistance in preclinical models, while ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!