Lactate-fueled enzyme rewrites gene expression to drive pulmonary arterial hypertension
Pulmonary arterial hypertension, a relentless and often fatal disease in which the blood vessels of the lungs progressively narrow and ...
Tag: lactylation
Lactate-Driven Epigenetic Shifts Reshape Liver Cancer Immunity
New research reveals that lactate-driven histone lactylation promotes Treg/Th17 imbalance in liver cancer via the PTPRM-STAT3 axis.
Epigenetics and Metabolism: The Two-Way Conversation Driving Liver Cancer
A new review in the Chinese Medical Journal maps how epigenetic modifications and metabolic reprogramming fuel each other in hepatocellular ...
How Lactate Rewrites Cell Fate: The Lactylation–Cell Death Axis That May Define Sepsis
A new review in the Journal of Advanced Research maps how sepsis-driven lactate accumulation chemically rewrites proteins through lactylation, tipping ...
Lactate emerges as both warning sign and driver of kidney injury after heart surgery
A new iScience study combining machine learning on over 6,500 patient records with rat and cell experiments shows that lactate ...
Lactate Fuels a Hidden Molecular Chain That Helps Liver Cancer Evade Immunity
A new study reveals how lactate-driven lactylation of histone and non-histone proteins in liver cancer activates a METTL3-FDFT1 cholesterol pathway ...
Cancer Cells Rewire Immune Neutrophils Through a Fumarate-Driven Metabolic Switch, Study Finds
A new Nature Cancer study reveals that the kinase GSK3β in colorectal tumor cells drives fumarate accumulation that epigenetically reprograms ...
Lactate Tags a Tumor Suppressor and Fuels Liver Cancer Growth
Researchers report that lactate-driven lactylation of the tumor suppressor OVOL2 at lysine 3, catalyzed by KAT8, weakens its nuclear function ...
Hidden Protein Modification Lets Pancreatic Cancer Evade Ferroptosis and Resist Chemotherapy
A new Nature Cancer study reveals how hypoxia-induced lactylation of MMSDH triggers ACSL4 degradation through propionylation, helping pancreatic cancer evade ...
Inside the Cancer Cell’s Second Genome: How Mitochondrial Gene Expression Fuels Tumors
A new review maps how metabolites chemically regulate every step of mitochondrial DNA replication, transcription and translation in cancer, revealing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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