Retrospective colorectal cancer study links nerve invasion to metastasis
A retrospective Chinese cohort study found that perineural invasion in resected colorectal cancer was independently associated with distant metastasis and ...
Tag: KRAS
Patient-derived cancer models expand dependency maps but expose new limits
Hundreds of patient-derived cancer models expanded dependency mapping and revealed vulnerabilities linked to mutations, cellular states and treatment history, while ...
Mouse Acinar Organoids Reveal Stage-Specific Control of Cell Plasticity
A mouse organoid system shows that defined signals can separately initiate acinar-to-ductal conversion, sustain metaplastic expansion and promote partial redifferentiation ...
Massive Turkish Genome Study Maps Hidden Mutation Patterns in Advanced Lung Cancer
A 1,500-patient next-generation sequencing study from Gazi University reveals EGFR and KRAS as dominant drivers in advanced NSCLC, with distinct ...
Dietary supplement Ca-αKG slows lung tumors in female mice but speeds growth in males, UCLA study finds
A UCLA study found that the dietary supplement calcium alpha-ketoglutarate slowed lung tumor growth in female mice while enlarging tumors ...
Mosaic RASopathies: how postzygotic mutations rewrite diagnosis and prognosis
A comprehensive genetic and clinicopathological analysis of 18 patients with mosaic RASopathies reveals that postzygotic mutations in HRAS, KRAS, BRAF, ...
How fruit fly tumors reveal ancient pathways that drive human RAS cancers
A new Drosophila cancer atlas called ART-D maps ten genetically defined Ras-driven tumor models through three stages of malignancy and ...
KRAS-mutant tumors flood themselves with adenosine to blind immune cells
Researchers report that oncogenic KRAS reprograms adenosine metabolism through NT5E upregulation and ADA suppression, creating an immunosuppressive tumor microenvironment that ...
Beyond the On-Off Switch: Chemical Tags on KRAS Reshape Cancer Drug Design
A new review in Advanced Cancer Research details how post-translational modifications regulate KRAS localization, activity, stability, and degradation, opening fresh ...
KRAS Blockade Paired with CTLA-4 Therapy Cracks Gastric Cancer Immune Shield
A preclinical study shows that combining KRASG12D inhibition with CTLA-4 blockade dismantles a TGF-beta-driven regulatory T cell shield, sensitizing KRAS-mutant ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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