Brain-Style NMDA Receptors Rewire Immune Cells Inside Tumors, Review Finds
A new review describes how NMDA glutamate receptors on myeloid cells drive calcium-dependent reprogramming toward immunosuppressive states, and how blocking ...
Tag: ion channels
Glutamate Levels Quietly Rewrite the Rules of Brain Signaling
New research shows that the concentration of glutamate at synapses, not just receptor subunit composition, tunes the conductance, rectification, and ...
Deleting a Potassium Channel Rewires How Glioblastoma Cells Respond to FLASH-Style Radiation
Deleting the BKCa potassium channel alters oxidative stress, DNA damage signaling and repair gene expression in glioblastoma cells exposed to ...
Human Stem Cell Assay Catches Seizure Risk Before Drugs Reach the Clinic
A human stem cell-based assay combining neuronal network recordings with ion channel profiling can detect drug seizure risk early, explain ...
BD2 Commits Over $13 Million to Decode Mood Switching in Bipolar Disorder
BD² has awarded more than $13 million in new grants to research teams at Harvard, Johns Hopkins, and Stanford to ...
Scientists Build Custom Protein Add-Ons to Rewire a Nanopore’s Electrical Behavior
Researchers have designed new protein subunits that integrate with a natural nanopore to create semisynthetic conduction pores with confirmed lumen ...
Rare Gene Variants May Explain Why Some Brains Are More Vulnerable to Concussion
Whole exome sequencing of 93 people with concussion history reveals a fivefold excess of rare damaging variants in ion channel ...
Cryo-EM Captures Hidden Pre-Active State That Switches On the Brain’s Fastest Receptors
Time-resolved cryo-electron microscopy with full and partial agonists has revealed the elusive pre-active state and complete gating pathway of AMPA ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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