Hippocampal Interneuron Subtypes Show Distinct Tonic Inhibition Plasticity
Brief NMDA receptor activation enhanced tonic GABAergic current density in a subset of non-OLM somatostatin-positive hippocampal interneurons while leaving OLM ...
Tag: interneurons
Organoids Reveal Interneuron Defects Drive Genetic Focal Epilepsy
Patient-derived ventral organoids show that GATOR1-related focal epilepsy involves MAFB-driven interneuron defects independent of mTOR hyperactivation.
New Open-Source Toolset Automates 3D Quantification of Fluorescent Colocalization
Researchers have introduced Bioloc3D, an open-source ImageJ and Python toolset that automates three-dimensional quantification of fluorescent elements and their colocalizations ...
Parvalbumin Protein Loss Linked to Epilepsy-Related Cognitive Impairment in Mice
A mouse study finds that restoring parvalbumin signaling in the hippocampus rescues epilepsy-related cognitive impairment by regulating CaMKIIα autophosphorylation and ...
The Plasticitome: Why Every Synapse in the Brain Learns by Its Own Rules
A new Frontiers Editorial argues that synaptic plasticity follows a diverse repertoire of learning rules across synapses, cell types, and ...
The Case of the Missing Mouse Pax6 Neuron: A Cross-Species Mix-Up Rewrites Brain Cell Taxonomy
A cross-species transcriptomic meta-analysis reveals that the mouse Pax6 interneuron subclass was never missing but mislabeled, while the primate Sncg ...
Glutamate Levels Quietly Rewrite the Rules of Brain Signaling
New research shows that the concentration of glutamate at synapses, not just receptor subunit composition, tunes the conductance, rectification, and ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!