Coumarin Supercharges Natural Killer Cells to Fight Liver Cancer, Study Finds
New preclinical research shows that the plant compound coumarin activates natural killer cells, boosts their mitochondrial energy supply, and shrinks ...
Tag: interferon-gamma
Rare IL-15-Driven NK Cell Subset Supercharges T Cell Attack on Melanoma
Researchers have identified a bone marrow-derived CD11c-positive B220-positive NK cell subset selectively expanded by IL-15 that outperforms conventional NK cells ...
Immune Checkpoint TREM2 Emerges as a Switch to Supercharge CAR Macrophages Against Breast Cancer
New research shows that blocking the TREM2 receptor reprograms HER2-targeted CAR macrophages from suppressive to inflammatory, tumor-engulfing cells in breast ...
Gum Disease Protein Mfa1 Supercharges Anti–PD-L1 Cancer Immunotherapy in Mice
A recombinant adhesion protein from the gum disease bacterium Porphyromonas gingivalis activates dendritic cells through TLR2 and boosts the anti-tumor ...
Rewired 2B4 Signal Gives CAR-NK Cells a Lasting Anti-Cancer Edge
Researchers engineered an activation-biased 2B4 costimulatory domain that boosts interferon-gamma production and sustains the killing stamina of CD5-targeting CAR-NK92 cells ...
Midlife Obesity May Quietly Disarm the Body’s Natural Killer Cells
New research in Aging Cell shows that natural killer cell numbers, maturation, and antitumor function decline during midlife obesity, particularly ...
Gut Enzyme LRRK2 Rises in Crohn’s Disease but Not in Parkinson’s or REM Sleep Disorder
A French study finds colonic LRRK2 expression is strongly increased in Crohn's disease but not elevated in Parkinson's disease or ...
Galectin-9 Emerges as a Key Driver of Immune Evasion in Cervical Cancer Progression
A multi-omics study traces cervical carcinogenesis from normal tissue to invasive cancer and identifies galectin-9-driven immune evasion as a promising ...
T Cells Can Wipe Out Tumors Without Ever Recognizing Them
New research shows that activating bystander T cells inside tumors triggers antigen-independent tumor killing through cytokines, nitric oxide and innate ...
Immune Cells That Kill Superbug Bacteria Directly Offer New Hope for Hard-to-Treat Lung Infections
New research in mice shows that IL-17A-producing γδ T cells directly kill Mycobacterium abscessus in the lung, revealing a promising ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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