S1416 trial results show PARP inhibitor benefit in “BRCA-like” breast cancer
Results from the SWOG S1416 clinical trial show that adding veliparib to chemotherapy can significantly extend progression-free survival (PFS) times ...
Tag: inhibitor
Study finds that patients with heart failure with improved ejection fraction benefit from the SGLT2 inhibitor dapagliflozin
With modern therapies for heart failure (HF) with reduced ejection fraction (HFrEF), some patients can improve their cardiac function during ...
When combined, a novel LSD1 inhibitor and an existing therapy enhance each other’s anti-cancer effects
A Medical University of South Carolina (MUSC) research team has developed novel compounds that show early promise at fighting the ...
The first potent COQ8 inhibitor targets ubiquinone biosynthesis
Inhibition of the COQ8 protein could be beneficial in the treatment of diseases such as cancer. COQ8 is needed for ...
Oncotarget | MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway
“In summary, our study shows that MK256, a potent and selective CDK8 inhibitor, is an effective negative STAT pathway regulator ...
Preliminary data suggest that ROS1 inhibitor, NVL-520, is well-tolerated and active in non-small cell lung cancer: first results from ARROS-1 phase I clinical trial
Barcelona, Spain: Preliminary data from a phase I clinical trial of a new drug called NVL-520 for patients with non-small ...
NCI-MATCH cancer trial finds a promising signal for the AKT inhibitor ipatasertib
Results from a single-arm phase 2 study of 32 patients with various cancer types harboring the rare AKT1 E17K mutation ...
AKT inhibitor shows signs of effectiveness in a patient trial matching drugs to tumour gene mutations
NB: this presentation will be the subject of an embargoed news briefing by co-author Dr Kevin Kalinsky on Monday 24 ...
New enzyme inhibitor shows promise for treating cancers, autoimmune diseases
Researchers at the University of Illinois Chicago have found a small molecule capable of manipulating an immune process that plays ...
Wistar scientists identify key biomarkers that reliably predict response to immune checkpoint inhibitor therapy for melanoma
PHILADELPHIA — (SEPTEMBER 19, 2022) — Immune checkpoint inhibitor (ICI) therapy is a type of treatment for melanoma, the deadliest ...
Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR Inhibitors
This study is carried out by Prof. Qiang Liu (Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University). In ...
RET inhibitor selpercatinib demonstrates durable responses in tumor-agnostic population
HOUSTON ― The highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses across multiple tumor types in ...
BioMed Valley Discoveries announces first patient dosed in phase II combination trial with ulixertinib (BVD-523), its first-in-class and best-in-class ERK inhibitor, in combination with hydroxychloroquine
Kansas City, MO. – Sept. 12, 2022—BioMed Valley Discoveries (BVD) announced that the first patient has been dosed in a ...
Gene inhibitor could help slow thrombosis in COVID-19 patients
HUNTINGTON, W.Va. – Findings from a new study at the Marshall University Joan C. Edwards School of Medicine show that ...
Novel brain-permeable BRAF inhibitor shows promise in more effectively reaching and treating melanoma brain metastasis
Credit: Vall d’Hebron Institute of Oncology (VHIO). Published in Cancer Research, findings reveal the potent and prolonged antitumor ...
A nanoparticle and inhibitor trigger the immune system, outsmarting brain cancer
ANN ARBOR, Michigan — Scientists at the University of Michigan Rogel Cancer Center were optimistic when they identified a small ...
Insilico Medicine announces novel 3CL protease inhibitor preclinical candidate for COVID-19 treatment
NEW YORK, May 24, 2022 --- Insilico Medicine, a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, today announced its nomination of ...
Strategy overcomes EZH2 inhibitor resistance in SMARCB1 mutated cancer
(Memphis, Tenn.—May 9, 2022) Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors ...
KRAS G12C inhibitor sotorasib may offer long-term clinical benefit in patients with non-small cell lung cancer
NEW ORLEANS – Patients with non-small cell lung cancer (NSCLC) treated with the KRAS G12C inhibitor sotorasib (Lumakras) had a ...
Screening study IDs inhibitor of key COVID virus enzyme
UPTON, NY—When the COVID-19 pandemic hit, scientists across the U.S. Department of Energy’s (DOE) national laboratory complex turned to the ...
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Anu, previously gropod, awarded nearly $1 million competitive grant from the National Science Foundation
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International group of scientists warns nuclear radiation has devastating impacts on ecosystems
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Null results research now published by major behavioral medicine journal
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Latin American and Caribbean researchers detail colonialism in ornithology
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In search of the invisible galaxy
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Can pigeons match wits with artificial intelligence?