PCSK9 Inhibitors Associated With Lower Dementia Risk in Adults Over Fifty
A global target trial emulation of over 31,000 matched patient pairs found that PCSK9 inhibitor use was associated with significantly ...
Tag: inhibitor
Common Medications May Alter Cancer Immunotherapy Outcomes
A narrative review published in Discover Medicine synthesizes preclinical and clinical evidence regarding the pharmacodynamic interactions between immune checkpoint inhibitors ...
Pembrolizumab Stabilizes Refractory GIST in Single Case Report
A case report documents nine months of stable disease in a patient with metastatic GIST treated with pembrolizumab after failing ...
Half of patients safely resumed cancer immunotherapy after heart concerns
A prospective single-centre cohort study found that half of patients with suspected cardiovascular immune-related adverse events were safely rechallenged with ...
Microscopy Reveals Hidden Scalp Inflammation During Alopecia Areata Treatment With JAK Inhibitors
A 60-week observational study reveals that reflectance confocal microscopy detects persistent subclinical follicular inflammation in severe alopecia areata despite marked ...
ECP Safe for Steroid-Refractory Immune Side Effects
In a prospective, single-arm, non-randomized phase-Ib/II clinical trial published in Nature Communications, researchers evaluated the safety and activity of extracorporeal ...
High activity of factor XI and C1 inhibitor in patients with ANCA-associated vasculitis: clinical and laboratory correlations with follow-up analysis of thrombotic events
A case-control study finds that patients with ANCA-associated vasculitis have higher activity of factor XI and C1 inhibitor, with specific ...
Antifungal Drug Butoconazole Suppresses Liver Cancer by Disrupting Cellular Energy Metabolism
Researchers have identified the antifungal drug butoconazole as a dual inhibitor of energy metabolism that suppresses liver cancer growth in ...
SGLT-2 Inhibitors Linked to Lower Liver Cancer Risk
A systematic review and meta-analysis finds an association between SGLT-2 inhibitor use and lower incident hepatocellular carcinoma in type 2 ...
MIF Inhibitor ISO-1 Cuts Liver Reperfusion Injury in Rat Transplant Model
A small-molecule inhibitor of macrophage migration inhibitory factor reduced early liver injury and improved graft microcirculation in a rat model ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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