Blocking AHR signaling curbs IL-8 in lab model of gut inflammation
Inhibiting the aryl hydrocarbon receptor (AHR) with a pharmacological blocker reduced expression of the inflammatory mediator IL-8 in a laboratory ...
Tag: inhibition
Classic 1980s arcade game validated as a window into executive functions
A large pre-registered study shows the Space Fortress task has strong psychometric properties and that performance depends most on inhibition ...
Blocking a Small RNA Protects Neurons From Stroke-Like Injury in Cell Model
New cell-based research shows that inhibiting the microRNA miR-140-5p improves neuronal survival, synaptic integrity and inflammatory responses after oxygen-glucose deprivation ...
Blocking ERG Protein Radiosensitizes ERG-Positive Prostate Cancers by Disabling DNA Repair
New research shows that inhibiting the ERG protein, overproduced in about half of prostate cancers, selectively impairs DNA double-strand break ...
Sodium selenite curbs bone loss in mice through GPX4-linked ferroptosis inhibition
Sodium selenite reduced ferroptosis and improved bone formation through GPX4 in cell and ovariectomized mouse experiments, preclinical findings that do ...
Plant compounds inhibit P. aeruginosa efflux pumps and biofilms in vitro
An in vitro study found that five plant compounds impaired efflux-pump activity and reduced P. aeruginosa PAO1 biofilm formation, with ...
ACSS2 inhibition boosts cabozantinib activity in liver cancer models
Preclinical hepatocellular carcinoma models showed that blocking ACSS2 or autophagy enhanced cabozantinib’s antitumor activity by disrupting a TFEB-linked protective response.
Moderate exercise protects against osteoarthritis in mice through gut microbes
In a mouse osteoarthritis model, moderate treadmill exercise altered the gut microbiota, lowered circulating lactate and reduced cartilage damage through ...
Mouse study links spinal Hsp90 inhibition to enhanced morphine pain relief through DUSP15 in CGRP neurons
In mice, spinal Hsp90 inhibition enhanced morphine pain relief, and DUSP15 knockdown in CGRP neurons reversed that effect.
LF3 restores 5-FU sensitivity in resistant colorectal cancer cell model
LF3 inhibited Wnt/β-catenin signaling and restored 5-fluorouracil sensitivity in a preclinical HCT-116 cell model of long-term chemotherapy resistance.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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