NAD+ Collapse Drives Senescent CD8+ T Cells That Worsen Ulcerative Colitis
A new study in Aging Cell shows that NAD+ metabolic collapse drives senescent CD8+ T cells to fuel ulcerative colitis ...
Tag: inflammatory bowel disease
Common ‘Forever Chemical’ PFNA Found to Ignite Gut Inflammation at Tiny Doses
New research shows that low-dose exposure to the forever chemical PFNA worsens intestinal inflammation by activating a caspase-11-dependent NLRP3 inflammasome ...
When Crohn’s Stomas Become Permanent: 40-Year Study Tracks Long-Term Outcomes in 422 Patients
A 43-year cohort study of 422 Crohn's disease patients shows that 87 percent of stomas created for anorectal disease ultimately ...
Stem Cell Therapy Eases Crohn’s Disease by Blocking Iron-Driven Cell Death
New research shows mesenchymal stem cells relieve Crohn's disease in mice by upregulating the enzyme CBS, restoring antioxidant defenses and ...
Global Study Maps Antibiotic Resistance Genes Across the Human Gut
A large-scale genomic and metagenomic study reveals how antibiotic resistance genes vary across populations, diseases and body sites, with pathogens ...
Patient Voices Before the Trial: How 26 Interviews Helped Push Daily ePRO Completion to 94% in Ulcerative Colitis Research
Structured pre-study interviews with 26 ulcerative colitis patients reshaped questionnaire wording, manuals, and support systems in the SIRIUS study, which ...
Lung Disease Strikes During Ulcerative Colitis Remission, Challenging Drug Explanation
Clinicians report a rare case of organising pneumonia arising in an ulcerative colitis patient in biochemical remission, arguing the lung ...
Common Bowel Drug Triggers Rare Pneumonia in Just Seven Days, Doctors Warn
A new case report documents one of the fastest recorded onsets of mesalazine-induced eosinophilic pneumonia, with lung symptoms appearing just ...
Environment, Not Just Genes: Exposome Framework Targets Inflammatory Bowel Disease Prevention
A new Perspective in Nature Reviews Gastroenterology & Hepatology proposes an exposome-based framework to prevent inflammatory bowel disease through targeted ...
Nerve Injury Protein NINJ2 Emerges as a Brake on Inflammatory Bowel Disease
Researchers found that the nerve repair protein NINJ2 protects mice from inflammatory bowel disease by suppressing ZBP1-driven PANoptosis in macrophages.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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